Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats.
Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats.
复制标题
内皮源性一氧化氮在控制老年雄性大鼠肾微血管中的作用。
DOI：
10.1152/ajpregu.1993.265.5.r1126
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
ManningJr,RD
中科院分区：
文献类型：
--
作者：
Reckelhoff,JF;ManningJr,RD
The objective of this study was to evaluate the role of nitric oxide (NO) in the regulation of whole kidney and glomerular hemodynamics during aging. After 2 wk of oral treatment with N-nitro-L-arginine methyl ester (L-NAME; 4.5 mg.kg body wt-1.day-1) to inhibit NO synthesis, male rats, aged 3-5, 13-15, and 21-24 mo, were studied by micropuncture. Blood pressure increased by 50% in old (21-24 mo) rats with L-NAME but only 20-30% in the two younger groups. With L-NAME, renal vascular resistance increased fivefold in old rats but only twofold in younger groups. Glomerular capillary pressure increased 20-30% in younger L-NAME rats and 60% in older rats. Afferent and efferent resistances increased dramatically, and the glomerular capillary ultrafiltration coefficient decreased in all L-NAME-treated rats but most strikingly in the 21- to 24-mo-old group. Acute infusion of L-arginine significantly attenuated the effects of NO synthase inhibition on arterial pressure and renal hemodynamics in both young and old rats. This study confirms that NO synthesis blockade has a greater effect on renal hemodynamics in aging rats and implies that NO may play a progressively more important role in controlling renal function with advancing age.
