Hypersensitivity to Inhaled Flour Allergens Comparison between Cereals
Hypersensitivity to Inhaled Flour Allergens Comparison between Cereals
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对吸入面粉过敏原过敏的谷物之间的比较
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
C. W. Wrigley
中科院分区：
文献类型：
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作者：
Brian A. Baldo;Steven A. Krilis;C. W. Wrigley
对小麦和黑麦敏感的受试者的血清进行放射性过敏吸附剂测试 (RAST) Hour 表明，与 12 种谷物（小麦、硬质小麦、黑小麦、谷物黑麦、大麦、黑麦草、燕麦、金丝雀草、水稻、玉米、高粱和约翰逊草）的种子提取物存在显着反应。根据分类关系和电泳测定的谷物提取物蛋白质组成对结果进行评估。四位鼻炎面包师血清中的 RAST 摄取量均较低，但明显高于非过敏性血清和脐带血清的水平。当用小麦及其近亲进行测试时，四名哮喘面包师的血清获得了更高的 RAST 吸收，但与更远亲的谷物仍然有相当高的反应性。 RAST 抑制实验以更直接的方式表明小麦、黑麦、大麦和燕麦的谷物提取物之间的交叉反应程度。一位面包师曾有过吸入黑麦面粉后出现比小麦面粉更严重的呼吸困难的病史。支气管激发试验证实了这一点，但该比较与点刺试验或白细胞释放的组胺估计结果并不明显一致。整体结果表明，谷物的麸皮层至少与面粉一样具有过敏性。
Radioallergosorbent testing (RAST) of sera from subjects sensitized to wheat and rye Hour indicated that there is significant reaction with seed extracts of 12 cereals (wheat, durum wheat, triticale, cereal rye, barley, rye grass, oats, canary grass, rice, maize, sorghum and Johnson grass). Results were evaluated in terms of taxonomic relationships and of the electrophoretically determined protein composition of the cereal extracts. RAST uptakes were uniformly low in sera from four rhinitic bakers, yet were significantly above the levels for non‐allergic and cord sera. Much higher RAST uptakes were obtained with sera from four asthmatic bakers when tested with wheat and its close relatives, but there was still reasonably high reactivity with more distantly related cereals. RAST inhibition experiments indicated in a more direct way the extent of cross‐reactivity between grain extracts of wheat, rye, barley and oats. One baker had a history of more severe attacks of breathlessness following inhalation of rye flour compared with wheat Hour. This was confirmed by bronchial challenge testing, but the comparison was not obviously consistent with the results of prick testing or estimation of histamine released from his leucocytes. The results as a whole suggested that the bran layers of cereal grains are at least as allergenic as flour.