Cannabis abuse and dependence in kidney transplant candidates.
Cannabis abuse and dependence in kidney transplant candidates.
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肾移植候选人的大麻滥用和依赖。
DOI：
10.1016/j.jpsychores.2019.04.004
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发表时间：
2019
影响因子：
4.7
通讯作者：
Schneekloth,TerryD
中科院分区：
文献类型：
--
作者：
Stark,AmyL;Hickson,LaTonyaJ;Larrabee,BethR;Thusius,NuriaJ;Karpyak,VictorM;Hall-Flavin,DanielK;Schneekloth,TerryD
目的大麻是普通人群中最常用的非酒精性麻醉剂。没有一致的指导方针大麻滥用和依赖（CAD）对肾移植候选人的影响。本研究的目的是表征合并冠心病的肾移植候选人，并检查冠心病对移植候选人的影响。方法对某三级中心2012 - 2016年符合CAD诊断标准的肾移植候选者进行回顾性队列研究。对候选人进行精神和物质使用障碍（sud）、家族史和医学变量的审查。队列按照冠心病的严重程度和移植名单状态进行分组进行比较。统计分析包括连续变量的Kruskal-Wallis检验和分类变量的Fisher精确检验。结果2067例肾移植候选者中有61例（3%）符合CAD标准，其中13例（21%）接受了移植。在61人中，58%每天吸食大麻，47%有酒精依赖史，31%有其他非法药物依赖史，38%是吸烟者，60%有SUD家族史，分别有42%和27%有抑郁和焦虑障碍。冠心病严重程度与移植名单呈负相关；滥用大麻的人比依赖大麻的人更常被列入名单（67%对33%，p= ）。学习结束时。三个案例演示说明了大麻相关问题。结论：在该队列中，与其他SUD人群相似，合并冠心病的肾移植候选者有较高的其他物质使用障碍、精神合并症和强烈的成瘾家族史。这些发现对移植前的筛查和治疗以及移植后的监测具有重要意义。
ObjectiveCannabis is the most commonly used non-alcohol intoxicant in the general population. There are no consistent guidelines on the implications of cannabis abuse and dependence (CAD) in kidney transplant candidates. The aims of this study were to characterize kidney transplant candidates with comorbid CAD and examine the implications of CAD on transplant candidacy.MethodThis was a retrospective cohort study of kidney transplant candidates meeting diagnostic criteria for CAD at a tertiary center from 2012 to 2016. Candidates were reviewed for psychiatric and substance use disorders (SUDs), family history, and medical variables. The cohort was divided by severity of CAD and transplant listing status for comparisons. Statistical analysis included Kruskal-Wallis tests for continuous variables and Fisher's Exact Test for categorical variables.ResultsSixty-one of 2067 (3%) kidney transplant candidates met criteria for CAD, and 13/61 (21%) underwent transplantation. Of 61, 58% smoked cannabis daily, 47% had alcohol dependence history, 31% had other illicit drug dependencies, 38% were smokers, 60% had a SUD family history, and 42% and 27% had depressive and anxiety disorders, respectively. Severity of CAD was inversely associated with transplant listing; those with cannabis abuse were more often listed than those with dependence (67% vs 33%,p= .02) by study end. Three case presentations illustrate cannabis-related issues.ConclusionIn this cohort, kidney transplant candidates with comorbid CAD have high prevalence of other substance use disorders, psychiatric comorbidities, and strong family histories of addictions that resemble other SUD populations. These findings have implications for pre-transplant screening and treatment and post-transplant monitoring.
关于移植候选人使用大麻的争论：关于大麻健康影响的最新医学证据
影响因子：
2.2
作者：
K. Coffman
通讯作者：
K. Coffman
撤回：使用大麻对心脑血管死亡率的影响：一项使用国家健康和营养检查调查相关死亡率文件的研究
影响因子：
8.3
作者：
Barbara A. Yankey;R. Rothenberg;S. Strasser;Kim Ramsey;I. Okosun
通讯作者：
I. Okosun