Potential Role of Phospholipids in Determining the Internal Tissue Distribution of Perfluoroalkyl Acids in Biota
Potential Role of Phospholipids in Determining the Internal Tissue Distribution of Perfluoroalkyl Acids in Biota
复制标题
DOI：
10.1021/es304430r
复制
发表时间：
2012-11-20
影响因子：
11.4
通讯作者：
Wania, Frank
中科院分区：
文献类型：
--
作者：
Armitage, James M.;Arnot, Jon A.;Wania, Frank
(PFAAs) remain highly relevant from both a scientific and regulatory perspective. Unlike neutral hydrophobic organic contaminants which exhibit the highest wet weight concentrations in adipose tissue, the highest levels of PFAAs in biota are typically measured in liver and blood samples. 1 This pattern of internal tissue distribution is hypothesized to largely reflect the role of PFAA− protein interactions in determining the sorption capacity of the organism and its various organs. Based on recent work developing and evaluating a mechanistically based bioconcentration model for ionogenic organic chemicals (IOCs) in fish, 2 we propose an alternative hypothesis, namely that the bioaccumulation potential and internal tissue distribution of perfluoroalkyl acids (PFAAs) are strongly influenced by phospholipids. The objective of this Viewpoint is to encourage further empirical studies to evaluate this assertion.Research into the interactions of PFAAs with proteins has predominantly focused on bovine serum albumin (BSA) and various fatty acid binding proteins (FABP). However, these data have yet to be used to derive a mechanistically based model capable of relating external concentrations of PFAAs to both internal concentrations and internal tissue distribution. It is already clear that bulk protein fraction in tissues cannot successfully explain the observed tissue distribution of PFAAs. For example, liver and muscle tissue have similar bulk protein contents, 3 whereas reported wet weight concentrations of PFAAs are typically many times higher in liver than in muscle. 1
