Successful treatment of a severe cannabinoid toxicity using extracorporeal therapy in a dog
Successful treatment of a severe cannabinoid toxicity using extracorporeal therapy in a dog
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DOI：
10.1111/vec.12899
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发表时间：
2019-10-22
影响因子：
1.3
通讯作者：
Vigani, Alessio
中科院分区：
文献类型：
--
作者：
Culler, Christine A.;Vigani, Alessio
目的描述使用体外治疗（ECT）治疗严重高脂血症犬的严重大麻素中毒。病例摘要一只7个月大的雌性完整拉布拉多犬出现癫痫发作和严重感觉过敏，多种抗惊厥药物无效，需要异丙酚全身麻醉和机械通气诱导。狗的尿液在尿液药物测试中产生了 δ-9-四氢大麻酚 (THC) 的强烈阳性信号，并且主人确认了其接触过 THC 油。血液检查显示严重高脂血症，因此静脉注射脂肪乳剂被认为是禁忌。该犬接受了 3 小时的 ECT 疗程，依次使用木炭血液灌流和血液透析。治疗期间神经系统体征有所改善，机械通气停止。治疗结束后，狗的精神状态立即显着改善，癫痫发作和感觉过敏停止，但仍存在中度共济失调。 ECT 治疗结束后，该狗住院 36 小时以进行持续监测。该狗完全康复并成功出院。提供新的或独特的信息据作者所知，这是第一份记录 ECT 治疗兽医 THC 中毒的报告。 ECT 可被视为标准治疗难治的严重 THC 中毒或严重高脂血症妨碍使用静脉注射脂肪乳剂的情况的一种治疗选择。
ObjectiveTo describe the use of extracorporeal therapy (ECT) to treat severe cannabinoid intoxication in a dog with severe hyperlipidemia.Case SummaryA 7-month-old female intact Labrador Retriever presented with seizures and severe hyperesthesia that were refractory to multiple anticonvulsant medications and required induction of general anesthesia with propofol and mechanical ventilation. The dog's urine yielded a strong positive signal for delta-9-tetrahydrocannabinol (THC) on urine drug test and exposure to THC oil was confirmed by the owner. Bloodwork revealed severe hyperlipidemia such that IV lipid emulsion was considered contraindicated. The dog was treated with a 3-hour ECT session, using charcoal hemoperfusion and hemodialysis in series. Neurologic signs improved during the session and mechanical ventilation was discontinued. Immediately after the session, the dog's mentation was significantly improved and seizures and hyperesthesia had ceased, although the dog remained moderately ataxic. The dog was hospitalized for 36 hours following the ECT session for continued monitoring. The dog fully recovered and was successfully discharged.New or Unique Information ProvidedTo the authors' knowledge, this is the first published report to document ECT to treat THC intoxication in veterinary medicine. ECT may be considered as a treatment option for severe THC intoxication that is refractory to standard therapy or where severe hyperlipidemia precludes use of IV lipid emulsions.