Neurobiology - Inhibitor of neurite outgrowth in humans
Neurobiology - Inhibitor of neurite outgrowth in humans
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DOI：
10.1038/35000287
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发表时间：
2000-01-27
期刊：
影响因子：
64.8
通讯作者：
Walsh, FS
中科院分区：
文献类型：
--
作者：
Prinjha, R;Moore, SE;Walsh, FS
一般认为轴突在成年中枢神经系统中不能再生。神经胶质瘢痕、神经营养因子的缺乏以及与髓鞘（绝缘轴突鞘）相关的生长抑制分子造成的物理屏障导致了抑制。这些分子包括蛋白聚糖、髓鞘相关糖蛋白，以及牛脑中的两种称为Nogo的蛋白质。我们已经使用这个牛的序列，以确定humanNogo基因，并已分离的互补DNA克隆编码三种不同的Nogo亚型，是有效的抑制剂的神经突生长，这可能有助于阻止再生的中枢神经系统在成年人。
Axons are generally believed to be incapable of regeneration in the adult central nervous system,. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin,,, the insulating axon sheath. These molecules include proteoglycans, myelin-associated glycoprotein,and, in bovine brain, two proteins called Nogo,,. We have used this bovine sequence to identify the humanNogogene and have isolated complementary DNA clones encoding three different Nogo isoforms that are potent inhibitors of neurite outgrowth and which may help block the regeneration of the central nervous system in adults.