Gamma tACS over the temporal lobe increases the occurrence of Eureka! moments
Gamma tACS over the temporal lobe increases the occurrence of Eureka! moments
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DOI：
10.1038/s41598-019-42192-z
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发表时间：
2019-04
影响因子：
4.6
通讯作者：
E. Santarnecchi;G. Sprugnoli;E. Bricolo;G. Costantini;S. Liew;C. Musaeus;C. Salvi;Á. Pascual-Leone-Á.-Pascual-Leon
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作者：
E. Santarnecchi;G. Sprugnoli;E. Bricolo;G. Costantini;S. Liew;C. Musaeus;C. Salvi;Á. Pascual-Leone-Á.-Pascual-Leon
一个问题的解决方案可能会表现为一系列意想不到的、不可预测的清晰。SuchEureka！事件，或洞察时刻，是人类认知中最令人着迷的谜团之一，其神经生理学基础似乎包括右顶叶和颞叶脑区α和γ带内振荡活动的作用。我们在31名健康受试者身上验证了这一假设，使用经颅交流电刺激(TACS)分别外部放大右侧顶叶和颞叶的α(10 赫兹)和γ(40 赫兹)活动。在右颞叶的γ-Tacs测试中，我们观察到在一项言语洞察任务中，准确率有所提高。此外，脑电数据显示刺激后双侧颞叶的γ频谱功率增加。此外，刺激前获得的静息状态功能磁共振数据表明，右侧颞叶Tacs的行为反应与双侧颞叶的功能连通性之间存在相关性，这与脑电显示的双侧γ频段的增加一致。总体而言，结果表明，通过特定频率的非侵入性脑刺激，可以增加人类产生Eureka！时刻的可能性。
The solution to a problem might manifest itself as a burst of unexpected, unpredictable clarity. SuchEureka!events, or Insight moments, are among the most fascinating mysteries of human cognition, whose neurophysiological substrate seems to include a role for oscillatory activity within the α and γ bands in the right parietal and temporal brain regions. We tested this hypothesis on thirty-one healthy participants using transcranial Alternating Current Stimulation (tACS) to externally amplify α (10 Hz) and γ (40 Hz) activity in the right parietal and temporal lobes, respectively. During γ-tACS over the right temporal lobe, we observed an increase in accuracy on a verbal insight task. Furthermore, electroencephalography (EEG) data revealed an increase in γ spectral power over bilateral temporal lobes after stimulation. Additionally, resting-state functional MRI data acquired before the stimulation session suggested a correlation between behavioral response to right temporal lobe tACS and functional connectivity of bilateral temporal lobes, in line with the bilateral increase in γ band revealed by EEG. Overall, results suggest the possibility of enhancing the probability of generatingEureka!moments in humans by means of frequency-specific noninvasive brain stimulation.