Role of heme and heme-proteins in trypanosomatid essential metabolic pathways.
Role of heme and heme-proteins in trypanosomatid essential metabolic pathways.
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DOI：
10.4061/2011/873230
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cricco JA
中科院分区：
文献类型：
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作者：
Tripodi KE;Menendez Bravo SM;Cricco JA
在世界范围内，锥虫是已知的几种高度致残且通常致命的疾病的病原体，如恰加斯病（克氏锥虫），利什曼病（利什曼原虫属），和非洲锥虫（布氏锥虫）。在其整个生命周期中，它们必须科普各种环境条件，而这些过程所涉及的机制对它们的生存至关重要。本文综述了血红素在这些原生动物几种重要代谢途径中的作用。尽管锥虫缺乏完整的血红素生物合成途径，但我们的讨论重点是重要的血红素蛋白（如细胞色素）所发挥的代谢作用。虽然Tritryp基因组计划中注释了几个不同类型细胞色素的基因，涉及线粒体呼吸，多不饱和脂肪酸代谢和甾醇生物合成，但编码的蛋白质尚未深入研究。我们指出，我们的注意力到这些蛋白质的功能，适合被认为是合理设计的杀锥虫剂的相关方面。
Around the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease (Trypanosoma cruzi), leishmaniasis (Leishmania spp.), and African trypanosomiasis (Trypanosoma brucei). Throughout their life cycle, they must cope with diverse environmental conditions, and the mechanisms involved in these processes are crucial for their survival. In this review, we describe the role of heme in several essential metabolic pathways of these protozoans. Notwithstanding trypanosomatids lack of the complete heme biosynthetic pathway, we focus our discussion in the metabolic role played for important heme-proteins, like cytochromes. Although several genes for different types of cytochromes, involved in mitochondrial respiration, polyunsaturated fatty acid metabolism, and sterol biosynthesis, are annotated at the Tritryp Genome Project, the encoded proteins have not yet been deeply studied. We pointed our attention into relevant aspects of these protein functions that are amenable to be considered for rational design of trypanocidal agents.