eEF1A2 as a Putative Oncogene

eEF1A2 as a Putative Oncogene
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DOI：
10.1111/j.1749-6632.2009.04909.x
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发表时间：
2009-01-01
期刊：
NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS
影响因子：
--
通讯作者：
Surh, Young-Joon
Surh, Young-Joon
中科院分区：
其他
文献类型：
--
作者：
Lee, Mee-Hyun;Surh, Young-Joon

文献摘要

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蛋白延伸因子eEF1A2在肿瘤发生中的作用的第一个证据是由Anand及其同事报道的，他们证明eEF1A2在约30%的卵巢肿瘤和一些已建立的卵巢癌细胞中过表达。这种异常表达与不良预后相关。自这一发现以来，已有几份报告表明eEF1A2可作为各种癌症的诊断标志物。这篇综述强调了eEF1A2的致癌潜力。
The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this discovery, there have been several reports suggesting eEF1A2 as a diagnostic marker in various cancers. This review highlights the oncogenic potential of eEF1A2.