Hypertension Analysis of Stress Reduction Using Mindfulness Meditation and Yoga: Results From the Harmony Randomized Controlled Trial
Hypertension Analysis of Stress Reduction Using Mindfulness Meditation and Yoga: Results From the Harmony Randomized Controlled Trial
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DOI：
10.1093/ajh/hpt134
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Tobe, Sheldon W.
中科院分区：
文献类型：
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作者：
Blom, Kimberly;Baker, Brian;Tobe, Sheldon W.
HARMONY研究是一项随机对照试验，旨在研究为期8周的正念减压（MBSR）计划对未服药的1期高血压参与者血压（BP）降低的疗效。方法根据动态血压诊断为1期高血压的参与者随机接受MBSR治疗8周或等待控制。主要结果分析评估了两组从基线到第12周的清醒和24小时动态血压变化是否有显著差异。结果：本研究共纳入101名成人（38%为男性），基线平均24小时动态血压为1357.9/825.8mmHg，白天动态血压为1407.7/876.3mmHg。在第12周，即时干预组24小时动态血压相对于基线的变化为0.46.7/0.04.9 mm Hg，等待名单对照组为0.47.8/0.44.6 mm Hg。所有动态血压参数在干预和等待名单控制之间没有显著差异。二次组内分析发现，与基线相比，MBSR后的血压小幅下降，发现仅限于女性受试者在性别analysis.CONCLUSIONS MBSR没有降低动态血压的统计学或临床显着量在未经治疗的，阶段1高血压患者相比，等待名单对照组。它留下了未经测试的MBSR是否可能是有用的，以降低血压，通过改善治疗高血压参与者的依从性。
BACKGROUND The HARMONY study was a randomized, controlled trial examining the efficacy of an 8-week mindfulness-based stress reduction (MBSR) program for blood pressure (BP) lowering among unmedicated stage 1 hypertensive participants.METHODS Participants diagnosed with stage 1 hypertension based on ambulatory BP were randomized to either immediate treatment of MBSR for 8 weeks or wait-list control. Primary outcome analysis evaluated whether change in awake and 24-hour ambulatory BP from baseline to week 12 was significantly different between the 2 groups. A within-group before and after MBSR analysis was also performed.RESULTS The study enrolled 101 adults (38% male) with baseline average 24-hour ambulatory BP of 1357.9/825.8mm Hg and daytime ambulatory BP of 1407.7/876.3 mmHg. At week 12, the change from baseline in 24-hour ambulatory BP was 0.46.7/0.04.9mm Hg for the immediate intervention and 0.47.8/0.44.6mm Hg for the wait-list control. There were no significant differences between intervention and wait-list control for all ambulatory BP parameters. The secondary within-group analysis found a small reduction in BP after MBSR compared with baseline, a finding limited to female subjects in a sex analysis.CONCLUSIONS MBSR did not lower ambulatory BP by a statistically or clinically significant amount in untreated, stage 1 hypertensive patients when compared with a wait-list control group. It leaves untested whether MBSR might be useful for lowering BP by improving adherence in treated hypertensive participants.