Substance P and vasoactive intestinal peptide influence polyamine metabolism in salivary glands of the rat.
Substance P and vasoactive intestinal peptide influence polyamine metabolism in salivary glands of the rat.
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P物质和血管活性肠肽影响大鼠唾液腺中的多胺代谢。
DOI：
10.1111/j.1748-1716.1989.tb08684.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
E. Rosengren
中科院分区：
文献类型：
--
作者：
J. Ekström;B. Nilsson;E. Rosengren
连续静脉输注不同剂量的神经肽P物质或血管活性肠肽刺激腮腺、舌下腺和颌下腺3小时，测定多胺腐胺、亚精胺、精胺和N1-乙酰亚精胺的浓度以及鸟氨酸脱羧酶的活性。这种酶催化腐胺的合成，是多胺形成的关键酶。血管活性肠肽引起最显着的效果，最显着的发现是在舌下腺中，发现鸟氨酸脱羧酶活性增加了100倍以上，伴随着这些腺体中腐胺水平的增加，在输注结束后立即将其去除。相反，当输注结束后 5 小时去除腺体时，鸟氨酸脱羧酶的活性或腐胺浓度不再增加，但现在发现亚精胺和精胺增加。有趣的是，大鼠主要唾液腺中多胺代谢的副交感非肾上腺素能、非胆碱能调节在舌下腺中最为主导。
In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of the neuropeptides substance P or vasoactive intestinal peptide at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activity of ornithine decarboxylase were determined. This enzyme catalyses the synthesis of putrescine and is the key enzyme in polyamine formation. Vasoactive intestinal peptide induced the most marked effects, and the most conspicuous findings were made in the sublingual glands, where the ornithine decarboxylase activity was found to have increased more than 100-fold, accompanied by an increased level of putrescine in those glands which were removed immediately after the end of the infusion. When, instead, the glands were removed 5 h after the end of the infusion there was no longer any increase in the activity of ornithine decarboxylase or in putrescine concentration, but now spermidine and spermine were found to be increased. Interestingly, the parasympathetic non-adrenergic, non-cholinergic regulation of polyamine metabolism in the major salivary glands of the rat is most predominant in the sublingual glands.