Sensitivity of the renal medullary circulation to plasma vasopressin
Sensitivity of the renal medullary circulation to plasma vasopressin
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DOI：
10.1152/ajpregu.1996.271.3.r647
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发表时间：
1996-09-01
影响因子：
2.8
通讯作者：
Cowley, AW
中科院分区：
文献类型：
--
作者：
Franchini, KG;Cowley, AW
本文研究了血浆精氨酸加压素(AVP)的生理变化对肾皮质和髓质血流分布的影响。为了能够在循环AVP的低生理范围内进行研究，进行了急性去大脑。用埋置光纤和激光多普勒血流仪测量肾皮质和髓质微循环血流量的变化，用渡越时间超声仪测量肾总血流量。静脉滴注递增剂量AVP时，当血浆AVP由2.9 pg/ml递增至11.2pg/ml时，平均动脉压(98+/-3 mm Hg)、肾总血流量(8.2+/-0.6 m l)。分钟(-1)。G肾(-1)，皮质微循环血流量(2.11+/-0.28V)不变，肾髓质微循环血流量递减。当循环AVP水平从2.8pg/ml增加到5.0pg/ml时，髓血流量显著减少，同时伴有尿液渗透压升高。这些数据表明，供肾髓质循环的血管在适度限水的血浆AVP浓度范围内是敏感的。髓质循环对AVP的敏感性与髓质集合二重唱的表现相似。
Studies were carried out to determine the effects of physiological changes of plasma arginine vasopressin (AVP) on blood flow distribution in the renal cortex and medulla. Acute decerebration was performed so that studies could be carried out within the low physiological range of circulating AVP. Changes of renal cortical and medullary microcirculatory blood flow were measured with implanted optical fibers and laser-Doppler flowmetry, and total renal blood flow was measured with transit-time ultrasonography. During intravenous infusion of increasing doses of AVP, when plasmaAVP was increased in steps from 2.9 to 11.2 pg/ml by intravenous infusion, mean arterial pressure (98+/-3 mmHg), total renal blood flow (8.2+/-0.6 ml . min(-1). g kidney(-1)), and blood flow in the microcirculation of the cortex (2.11+/-0.28 V) remained unchanged, whereas that in the renal medulla decreased progressively. Medullary flow was significantly reduced when circulating levels of AVP increased from a control level of 2.8 to 5.0 pg/ml. The reductions of medullary flow were accompanied by parallel increases of urine osmolality. These data indicate that the vessels supplying the renal medullary circulation are sensitive within the range of plasma AVP concentrations observed with moderate water restriction. The medullary circulation exhibits a sensitivity to AVP that parallels that found in the medullary collecting duets.