Male pattern baldness and its association with coronary heart disease: a meta-analysis.
Male pattern baldness and its association with coronary heart disease: a meta-analysis.
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DOI：
10.1136/bmjopen-2012-002537
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发表时间：
2013
期刊：
影响因子：
2.9
通讯作者：
Kadowaki T
中科院分区：
文献类型：
--
作者：
Yamada T;Hara K;Umematsu H;Kadowaki T
目的：探讨男性型秃发与冠心病的关系。观察性研究的荟萃分析。Medline和Cochrane图书馆检索了截至2012年11月发表的文章，关键词包括“秃顶”和“冠心病”，并检索了这些研究的参考文献列表。观察性研究确定了与秃顶相关的冠心病风险评估报告。两名观察员独立评估资格，提取数据并评估偏倚的可能性。校正相对危险度（RR）和95% CI采用dersimonan - laird随机效应模型估计。共选择了850项可能研究、3项队列研究和3项病例对照研究（36990名受试者）。在队列研究中，严重秃顶男性患冠心病的校正RR为1.32 （95% CI 1.08 ~ 1.63, p=0.008, I2=25%）。对年轻男性（<55岁或≤60岁）的分析显示，冠心病与严重秃顶的相关性相似（RR 1.44, 95% CI 1.11 ~ 1.86, p=0.006, I2=0%）。在3项采用改良Hamilton量表的研究中，顶点秃顶与冠心病存在相关性，且相关性取决于秃顶的严重程度(严重顶点：RR 1.48 (1.04 ~ 2.11, p=0.03)；中度顶点：RR 1.36 (1.16 ~ 1.58, p<0.001)；轻度顶点：RR 1.18 （1.04 ~ 1.35, p<0.001）。然而，额顶秃顶与冠心病无关（RR 1.11 (0.92 ~ 1.32, p=0.28)）。顶点秃顶，而不是额顶秃顶，与冠心病的风险增加有关。与冠心病的关系取决于顶点秃顶的严重程度，也存在于年轻男性中。因此，顶型秃顶可能比额型秃顶与动脉粥样硬化的关系更密切，但男性型秃顶与冠心病的关系值得进一步研究。
To confirm the association between male pattern baldness and coronary heart disease (CHD). Meta-analysis of observational studies. Medline and the Cochrane Library were searched for articles published up to November 2012 using keywords that included both ‘baldness’ and ‘coronary heart disease’ and the reference lists of those studies identified were also searched. Observational studies were identified that reported risk estimates for CHD related to baldness. Two observers independently assessed eligibility, extracted data and assessed the possibility of bias. The adjusted relative risk (RR) and 95% CI were estimated using the DerSimonian-Laird random-effect model. 850 possible studies, 3 cohort studies and 3 case–control studies were selected (36 990 participants). In the cohort studies, the adjusted RR of men with severe baldness for CHD was 1.32 (95% CI 1.08 to 1.63, p=0.008, I2=25%) compared to those without baldness. Analysis of younger men (<55 or ≤60 years) showed a similar association of CHD with severe baldness (RR 1.44, 95% CI 1.11 to 1.86, p=0.006, I2=0%). In three studies employing the modified Hamilton scale, vertex baldness was associated with CHD and the relation depended on the severity of baldness (severe vertex: RR 1.48 (1.04 to 2.11, p=0.03); moderate vertex: RR 1.36 (1.16 to 1.58, p<0.001); mild vertex: RR 1.18 (1.04 to 1.35, p<0.001)). However, frontal baldness was not associated with CHD (RR 1.11 (0.92 to 1.32, p=0.28)). Vertex baldness, but not frontal baldness, is associated with an increased risk of CHD. The association with CHD depends on the severity of vertex baldness and also exists among younger men. Thus, vertex baldness might be more closely related to atherosclerosis than frontal baldness, but the association between male pattern baldness and CHD deserves further investigation.