Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate
Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate
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pH响应型两亲性4-氨基喹啉 - 四苯乙烯共轭物逐步自组装过程的调控
DOI：
10.1039/d2nr05756e
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发表时间：
2023-01-19
期刊：
影响因子：
6.7
通讯作者：
Higuchi，Tsunehiko
中科院分区：
文献类型：
--
作者：
Hisamatsu，Yosuke;Cheng，Fangzhou;Higuchi，Tsunehiko
控制自组装的动力学过程并根据外部环境的变化切换其动力学性质是超分子聚合物在水中用于生物和生物医学应用领域的关键概念。本文报道了一种新的自组装两亲性4-氨基喹啉（4-AQ）-四苯乙烯（TPE）共轭物，该共轭物具有动力学可控的逐步自组装，并具有响应pH值切换其动力学性质的能力。4-AQ两亲物的自组装过程包括形成球形纳米颗粒，过渡到短纳米纤维，并在室温下生长出长度为~ 1 μm的长纳米纤维。自组装过程的时间尺度根据4-AQ部分在弱酸性至中性pH范围内的pH响应性而有所不同。因此，在室温下老化24小时后，4-AQ两亲物在pH 5.5下形成亚稳定的短纳米纤维，而在pH 7.4下形成亲油的长纳米纤维。此外，通过在7.4和5.5之间改变pH来切换动力学途径，实现了在RT下自发进行的细菌生长的调节。
Controlling the kinetic processes of self-assembly and switching their kinetic properties according to the changes in external environments are crucial concepts in the field of supramolecular polymers in water for biological and biomedical applications. Here we report a new self-assembling amphiphilic 4-aminoquinoline (4-AQ)-tetraphenylethene (TPE) conjugate that exhibits kinetically controllable stepwise self-assembly and has the ability of switching its kinetic nature in response to pH. The self-assembly process of the 4-AQ amphiphile comprises the formation of sphere-like nanoparticles, a transition to short nanofibers, and their growth to long nanofibers with ∼1 μm length scale at room temperature (RT). The timescale of the self-assembly process differs according to the pH-responsivity of the 4-AQ moiety in a weakly acidic to neutral pH range. Therefore, after aging for 24 h at RT, the 4-AQ amphiphile forms metastable short nanofibers at pH 5.5, while it forms thermodynamically favored long nanofibers at pH 7.4. Moreover, the modulation of nanofiber growth proceeding spontaneously at RT was achieved by switching the kinetic pathway through changing the pH between 7.4 and 5.5.