Germline configuration of nfkb2, c-rel and bcl3 in childhood acute lymphoblastic leukemia (ALL)
Germline configuration of nfkb2, c-rel and bcl3 in childhood acute lymphoblastic leukemia (ALL)
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DOI：
10.1038/sj.leu.2400778
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发表时间：
1997-08-01
期刊：
影响因子：
11.4
通讯作者：
Schmid, RM
中科院分区：
文献类型：
--
作者：
Liptay, S;Seriu, T;Schmid, RM
众所周知的NF-κ B/Rel转录因子家族是造血细胞谱系中生长、分化和凋亡的中心调节因子。越来越多的证据表明它们在恶性转化中的作用，特别是在淋巴瘤中。为探讨NF-κ B B/Rel基因在儿童急性淋巴细胞白血病（ALL）发病中的作用，应用Southern印迹杂交技术检测了140例ALL患儿的DNA。所有样本均显示nfkb 2、c-rel和bcl 3的种系构型，表明NF-κ B B/Rel家族的这些成员的结构改变即使在儿童ALL中存在也是极其罕见的。
The well-known family of NF-kappa B/Rel transcription factors is a central regulator of growth, differentiation and apoptosis in hematopoietic cell lineages. There is increasing evidence for their role in malignant transformation, especially in lymphomas. To study the possible involvement of NF-kappa B/Rel genes in the development of pediatric acute lymphoblastic leukemia (ALL), DNA samples from 140 patients were-examined by Southern blot analysis. All samples revealed germline configuration of nfkb2, c-rel, and bcl3, indicating that structural alterations of these members of the NF-kappa B/Rel family are extremely rare, if existing at all in childhood ALL.