Fabrication of nanofibrous tubular scaffolds for bone tissue engineering
Fabrication of nanofibrous tubular scaffolds for bone tissue engineering
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DOI：
10.1016/j.matlet.2016.07.015
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发表时间：
2016-11-01
影响因子：
3
通讯作者：
Xiao, Xiufeng
中科院分区：
文献类型：
--
作者：
Chen, Shunyu;He, Zhihang;Xiao, Xiufeng
以聚L-乳酸（PLLA）/1，4-二氧六环/水三元体系为研究对象，在输入电压为4.00 V，相分离温度为-15 ℃的条件下，采用离心法结合热致相分离技术制备了纳米纤维管状PLLA支架。蔗糖的加入导致具有互连孔的多孔支架的产生。输入电压是产生模拟生物系统结构特征的纳米纤维管状支架的关键因素。纳米纤维管状支架的表面为MC 3 T3-E1亚克隆14细胞的附着和增殖提供了良好的环境，显示出显著的骨组织再生潜力。(C)2016爱思唯尔B. V.保留所有权利。
Nanofibrous tubular poly(L-lactic acid) (PLLA) scaffolds were fabricated by centrifugation combined with thermally induced phase separation technique using PLLA/1,4-dioxane/water ternary system, at input voltage of 4.00 V and phase separation temperature of -15 degrees C. Addition of sucrose led to the generation of porous scaffolds with interconnected pores. Input voltage was the crucial factor to generate nanofibrous tubular scaffold that mimicked the structural features of the biological systems. The surface of nanofibrous tubular scaffold provided a good environment for attachment and proliferation of MC3T3-E1 subclone 14 cells, exhibiting significant potential for bone tissue regeneration. (C) 2016 Elsevier B.V. All rights reserved.