A polymorphism rs4705341 in the flanking region of miR-143/145 predicts risk and prognosis of colorectal cancer.
A polymorphism rs4705341 in the flanking region of miR-143/145 predicts risk and prognosis of colorectal cancer.
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miR-143/145 侧翼区域的 rs4705341 多态性可预测结直肠癌的风险和预后
DOI：
10.18632/oncotarget.11387
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发表时间：
2016-09-20
期刊：
影响因子：
--
通讯作者：
Gao L
中科院分区：
文献类型：
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作者：
Sun R;Chen P;Li L;Sun H;Nie X;Liang Y;Yuan F;Pu Y;Bai P;Zhang L;Gao L
本研究的目的是探讨miR-143/145侧翼区域rs4705341多态性对结直肠癌（CRC）风险的影响。采用聚合酶链反应-限制性片段长度多态性方法对1002例病例和1062例对照进行rs4705341多态性分析。我们发现miR-143/145 rs4705341在纯合子比较（校正OR = 0.66, 95%CI, 0.50-0.88, P = 0.004）、显性遗传模型（校正OR = 0.80, 95%CI, 0.67-0.96, P = 0.015）、隐性遗传模型（校正OR = 0.73, 95%CI, 0.56-0.94, P = 0.016）和等位基因比较（校正OR = 0.83, 95%CI, 0.73-0.94, P = 0.004）中显著降低结直肠癌易感性。分层分析显示rs4705341与分化状态、临床I-II期、患者有无淋巴结转移有关。此外，rs4705341GG患者的总生存期更长（调整后HR = 5.57, 95%CI, 0.95-32.68）。这些发现表明miR-143/145 rs4705341可能作为CRC发展和预后的潜在生物标志物。
The aim of this study was to investigate the effect of a polymorphism rs4705341 in the flanking region of miR-143/145 on the risk of colorectal cancer (CRC). The rs4705341 polymorphism was analyzed in 1002 cases and 1062 controls using a polymerase chain reaction-restriction fragment length polymorphism method. We found a significantly reduced CRC susceptibility with miR-143/145 rs4705341 in homozygote comparison (adjusted OR = 0.66, 95%CI, 0.50-0.88, P = 0.004), dominant genetic model (adjusted OR = 0.80, 95%CI, 0.67-0.96, P = 0.015), recessive genetic model (adjusted OR = 0.73, 95%CI, 0.56-0.94, P = 0.016), and allele comparison (adjusted OR = 0.83, 95%CI, 0.73-0.94, P = 0.004). Stratification analysis showed that the rs4705341 was related to differentiated status, clinical stage I-II, and patients without lymph node metastasis. Moreover, patients with rs4705341GG had a longer overall survival (adjusted HR = 5.57, 95%CI, 0.95-32.68). These findings indicate that the miR-143/145 rs4705341 may be used as a potential biomarker for the development and prognosis of CRC.