Glucose but not insulin or insulin resistance is associated with memory performance in middle-aged non-diabetic women: a cross sectional study
Glucose but not insulin or insulin resistance is associated with memory performance in middle-aged non-diabetic women: a cross sectional study
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DOI：
10.1186/s13098-015-0014-7
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发表时间：
2015-03-15
影响因子：
4.8
通讯作者：
Rolandsson, Olov
中科院分区：
文献类型：
--
作者：
Backestrom, Anna;Eriksson, Sture;Rolandsson, Olov
背景：血糖浓度升高似乎在记忆障碍中起作用，而且有研究表明，胰岛素也可能对认知功能产生负面影响。我们的目的是研究血糖、胰岛素或胰岛素抵抗是否与非糖尿病和非痴呆人群的情景记忆或语义记忆有关。方法：我们链接并匹配了两个基于人群的数据集，确定了291名参与者(127名男性和164名女性，平均年龄为50.7+/-8.0岁)。测试情景和语义记忆功能，分析空腹血浆胰岛素、空腹血糖和2小时血糖以及其他可能影响记忆功能的因素。由于男性和女性在记忆功能上表现出不同的结果，所以他们被分开进行了分析。结果：空腹血糖浓度越高，女性的事件记忆力越差(r=-0.08，95%CI-0.14；-0.01)，而男性则无相关性。在调整了年龄、空腹血糖、2小时血糖、体重指数、教育程度、吸烟、心血管疾病、高血压、胆固醇和体力活动后，女性和男性的血浆胰岛素水平和胰岛素抵抗与情景记忆或语义记忆无关。结论：空腹血糖而不是胰岛素可能影响中年女性的情景记忆。
Background: Elevated concentrations of plasma glucose appear to play a role in memory impairment, and it has been suggested that insulin might also have a negative effect on cognitive function. Our aim was to study whether glucose, insulin or insulin resistance are associated with episodic or semantic memory in a non-diabetic and non-demented population.Methods: We linked and matched two population-based data sets identifying 291 participants (127 men and 164 women, mean age of 50.7 +/- 8.0 years). Episodic and semantic memory functions were tested, and fasting plasma insulin, fasting plasma glucose, and 2-hour glucose were analysed along with other potential influencing factors on memory function. Since men and women display different results on memory functions they were analysed separately. Insulin resistance was calculated using the HOMA-IR method.Results: A higher fasting plasma glucose concentration was associated with lower episodic memory in women (r = -0.08, 95% CI -0.14; -0.01), but not in men. Plasma insulin levels and insulin resistance were not associated with episodic or semantic memory in women or in men after adjustments for age, fasting glucose, 2-hour glucose, BMI, education, smoking, cardiovascular disease, hypertension, cholesterol, and physical activity.Conclusions: This indicates that fasting glucose but not insulin, might have impact on episodic memory in middle-aged women.