Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor.
Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor.
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血小板衍生生长因子对 3T3 细胞上表皮生长因子受体的调节。
DOI：
10.1126/science.6254158
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Ross,R
中科院分区：
文献类型：
--
作者：
Wrann,M;Fox,CF;Ross,R
血小板衍生生长因子不与表皮生长因子（EGF）竞争结合鼠3T3细胞表面上的EGF受体，但其以两种方式调节EGF受体：（i）其诱导EGF受体的瞬时下调和（ii）其抑制EGF诱导的EGF受体的下调。这些数据表明两种激素的受体具有共同的细胞内化机制。
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.