The effect of a very low-calorie diet-induced weight loss on the severity of obstructive sleep apnoea and autonomic nervous function in obese patients with obstructive sleep apnoea syndrome
The effect of a very low-calorie diet-induced weight loss on the severity of obstructive sleep apnoea and autonomic nervous function in obese patients with obstructive sleep apnoea syndrome
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DOI：
10.1046/j.1365-2281.1998.00114.x
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发表时间：
1998-07-01
期刊：
影响因子：
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通讯作者：
Uusitupa, M
中科院分区：
文献类型：
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作者：
Kansanen, M;Vanninen, E;Uusitupa, M
本研究旨在探讨极低热量饮食（VLCD）诱导的体重减轻对阻塞性睡眠呼吸暂停综合征（OSAS）肥胖患者阻塞性睡眠呼吸暂停（OSA）严重程度、血压和心脏自主神经调节的影响。共对15名超重OSAS患者（14名男性和1名女性，体重114 +/- 20 kg，年龄52 +/- 9岁，范围39-67岁）进行了前瞻性研究。他们被建议每天遵循2.51-3.35 MJ（600-800千卡）的饮食，持续3个月。在研究开始时，患者接受夜间睡眠研究，自主神经功能测试和24小时心电图（ECG）记录。此外，还研究了15名年龄匹配的正常体重受试者。他们接受了Valsalva测试，深呼吸测试和静息心率变异性评估。在减肥期后重复睡眠研究和自主神经功能测试。体重显著下降（114 +/- 20 kg至105 +/- 21 kg，P
The aim of this study was to examine the effect of a very low-calorie diet (VLCD)-induced weight loss on the severity of obstructive sleep apnoea (OSA), blood pressure and cardiac autonomic regulation in obese patients with obstructive sleep apnoea syndrome (OSAS). A total of 15 overweight patients (14 men and one woman, body weight 114 +/- 20 kg, age 52 +/- 9 years, range 39-67 years) with OSAS were studied prospectively. They were advised to follow a 2.51-3.35 MJ (600-800 kcal) diet daily for a 3-month period. In the beginning of the study, the patients underwent nocturnal sleep studies, autonomic function tests and 24-h electrocardiograph (ECG) recording. In addition, 15 age-matched, normal-weight subjects were studied. They underwent the Valsalva test, the deep-breathing test and assessment of heart rate variability at rest. The sleep studies and autonomic function tests were repeated after the weight loss period. There was a significant reduction in weight (114 +/- 20 kg to 105 +/- 21 kg, P