The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus.
The actions of volatile anaesthetics on synaptic transmission in the dentate gyrus.
复制标题
挥发性麻醉剂对齿状回突触传递的作用。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
A. E. White
中科院分区：
文献类型：
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作者：
C. D. Richards;A. E. White
1.检查了四种挥发性麻醉剂对海马体外制备物诱发突触电位的作用。2.所有四种麻醉剂（乙醚，氟烷，甲氧氟烷和三氯乙烯）抑制的穿透路径和颗粒细胞之间的突触传递的浓度低于在完整的动物维持麻醉所需的。3.群体兴奋性突触后电位（epsp）并且皮层细胞的聚集放电（群体尖峰）在低于抑制穿通路径神经纤维的复合动作电位所需的麻醉剂浓度时被抑制。所研究的麻醉剂均未增加颗粒细胞放电所需的阈值去极化。此外，诱发的皮层eps的频率增强没有受到任何麻醉剂的影响。4.可以得出结论，所有四种麻醉剂都通过减少每个神经末梢响应传入齐射释放的递质量，或通过降低突触后膜对释放的递质的敏感性，或通过两种效应一起抑制齿状回中的突触传递。
1. The action of four volatile anaesthetics on the evoked synaptic potentials of in vitro preparations of the hippocampus were examined. 2. All four anaesthetics (ether, halothane, methoxyflurane and trichloroethylene) depressed the synaptic transmission between the perforant path and the granule cells at concentrations lower than those required to maintain anaesthesia in intact animals. 3. The population excitatory post‐synaptic potential (e.p.s.p.) and massed discharge of the cortical cells (population spike) were depressed at concentrations of the anaesthetics lower than those required to depress the compound action potential of the perforant path nerve fibres. None of the anaesthetics studied increased the threshold depolarization required for granule cell discharge. Furthermore, frequency potentiation of the evoked cortical e.p.s.p.s was not impaired by any of the anaesthetics studied. 4. It is concluded that all four anaesthetics depress synaptic transmission in the dentate gyrus either by reducing the amount of transmitter released from each nerve terminal in response to an afferent volley, or by decreasing the sensitivity of the post‐synaptic membrane to released transmitted or by both effects together.