Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD)
Clinical significance of homocysteine (hcy) on dementia in Parkinson's disease (PD)
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DOI：
10.1016/j.archger.2013.04.015
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发表时间：
2013-11-01
影响因子：
4
通讯作者：
Lee, Kwang-Soo
中科院分区：
文献类型：
--
作者：
Song, In-Uk;Kim, Joong-Seok;Lee, Kwang-Soo
认知功能障碍和痴呆是帕金森病常见的非运动症状。Hcy具有多种神经元和内皮细胞毒性。左旋多巴与hcy水平升高相关的临床意义及其对PD患者认知能力下降过程的影响尚不明确。我们进行这项研究是为了阐明韩国人群中PD与痴呆相关的hcy升高的临床意义。本研究共招募了33例无痴呆的PD患者（PDwoD）和28例伴痴呆的PD患者（PDD）与48例hc进行比较，以确认hcy作为PD相关痴呆的促进因素的价值。PD患者进行神经心理测试和神经学检查。所有患者和hc均常规测定血浆hcy水平。PDD组hcy水平高于PDD组和hc组。在考虑每一组pdwd和PDD时，hcy水平、PD症状持续时间、PD治疗持续时间或神经心理测试结果之间没有相互关联。总之，我们确定hcy水平与PD患者认知能力下降有关。然而，我们无法明确地证实hcy在PDD中的病理生理作用以及hcy与左旋多巴之间的关系。2013爱思唯尔爱尔兰有限公司版权所有。
Cognitive dysfunction and dementia are common non-motor symptoms of PD. hcy has various neuronal and endothelial cellular toxicities. The clinical relevance of the levodopa associated with elevated hcy level and its effect on the course of cognitive decline in PD are still undetermined. We conducted this study to clarify the clinical significance of elevated hcy in PD associated with dementia in the Korean population. A total of 33 PD patients without dementia (PDwoD) and 28 PD patients with dementia (PDD) who were recruited for this study were compared with 48 HCs to confirm the value of hcy as a contributing factor of dementia associated with PD. PD patients had neuropsychological tests and neurological examinations performed. The plasma hcy level was measured routinely in all patients and HCs. The hcy of PDD showed a higher hcy level than those of PDwoD as well as HCs. In considering each group of PDwoD and PDD, there were no intercorrelations between hcy levels, duration of PD symptoms, duration of PD treatment, or the results of neuropsychological tests. In conclusion, we ascertained that hcy level was related to the cognitive decline of PD patients. However we were unable to confirm a clear pathophysiologic role of hcy in PDD and the relationship between hcy and levodopa, significantly. (C) 2013 Elsevier Ireland Ltd. All rights reserved.