Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.
Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.
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DOI：
10.1038/sj.bjc.6603251
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发表时间：
2006-07-17
影响因子：
8.8
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中科院分区：
文献类型：
--
作者：
在不同的肿瘤实体中，趋化因子受体4(CXCR4)的表达与肿瘤的扩散和预后不良有关。因此，我们评估了CXCR4在人肝细胞癌中的表达是否起到了类似的作用。体外表达分析和功能分析，阐明CXCL12对人肝癌细胞株的影响。此外，对39例肝细胞癌组织中CXCR4的表达进行了半定量检测，并与肿瘤及患者的临床特征进行了相关分析。人肝细胞癌和肝癌细胞系显示不同强度的CXCR4表达。P53功能缺失对CXCR4的表达无影响。CXCL12可介导CXCR4在Huh7/Hep3B细胞中的核周转位，并增加Huh7细胞的侵袭能力。在肝细胞癌患者中，CXCR4的表达与局部肿瘤进展(T状态，P=0.006)、淋巴转移(N状态，P=0.005)和远处扩散(M状态，P=0.009)显著相关，并与3年生存率下降有关。综上所述，CXCR4的强表达与肝细胞癌的进展显著相关。
In different tumour entities, expression of the chemokine receptor 4 (CXCR4) has been linked to tumour dissemination and poor prognosis. Therefore, we evaluated, if the expression of CXCR4 exerts similar effects in human hepatocellular carcinoma (HCC). Expression analysis and functional assays were performed in vitro to elucidate the impact of CXCL12 on human hepatoma cells lines. In addition, expression of CXCR4 was evaluated in 39 patients with HCC semiquantitatively and correlated with both, tumour and patients characteristics. Human HCC and hepatoma cell lines displayed variable intensities of CXCR4 expression. Loss of p53 function did not impact on CXCR4 expression. Exposure to CXCL12 mediated a perinuclear translocation of CXCR4 in Huh7/Hep3B cells and increased the invasive potential of Huh7 cells. In HCC patients, CXCR4 expression significantly correlated with progressed local tumours (T-status; P=0.006), lymphatic metastasis (N-status; P=0.005) and distant dissemination (M-status; P=0.009), as well as with a decreased 3-year-survival rate (P=0.01). In summary, strong expression of CXCR4 is significantly associated with progressed hepatocellular cancer.
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影响因子：
8
作者：
Burger, M;Glodek, A;Burger, JA
通讯作者：
Burger, JA
DOI：
10.1073/pnas.2235846100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Rubin, JB;Kung, AL;Segal, RA
通讯作者：
Segal, RA
影响因子：
4.8
作者：
Helbig, G;Christopherson, KW;Nakshatri, H
通讯作者：
Nakshatri, H
影响因子：
64.8
作者：
Staller, P;Sulitkova, J;Krek, W
通讯作者：
Krek, W
DOI：
10.1164/rccm.200301-071oc
发表时间：
2003-06-15
影响因子：
24.7
作者：
Phillips, RJ;Burdick, MD;Strieter, RM
通讯作者：
Strieter, RM