Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study
Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study
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DOI：
10.1016/j.psyneuen.2015.08.027
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发表时间：
2015-12-01
影响因子：
3.7
通讯作者：
Neumann, Inga D.
中科院分区：
文献类型：
--
作者：
de Jong, Trynke R.;Menon, Rohit;Neumann, Inga D.
鼻内催产素（OXT）应用正在成为一种潜在的治疗与OXT系统（再）活动异常相关的社会情绪障碍。通过评估唾液中基础和刺激诱导的OXT浓度，使用简单的无压力采样程序（即OXT激发试验），可以简化对具有此类异常的患者的关键识别。因此，我们建立了里根斯堡催产素挑战（ROC）测试，以进一步验证唾液OXT浓度作为实用、可靠和灵敏的生物标志物。通过放射免疫测定法定量健康成年男性和女性志愿者在跑步（“跑步”）或性自我刺激（“性爱”）之前和之后在家中收集的样品中的OXT浓度。在哺乳期女性中，在母乳喂养前、期间和之后定量唾液OXT浓度。在进行特里尔社会压力测试（TSST）的健康成年参与者中监测唾液OXT沿着唾液皮质醇和心率。基于家庭的“跑步”和“性”挑战以及基于实验室的TSST引起唾液OXT的可量化的、快速的和一致的增加（10-15分钟后约2.5倍），这对于男性和女性是相似的。母乳喂养没有导致唾液OXT水平的可测量的增加，可能是因为错过了哺乳期OXT释放特征的短脉冲。与基础水平相比，唾液OXT浓度的增加）对家庭中的“跑步”和“性”或实验室中的心理社会应激（TSST）等挑战的反应。为了揭示ROC测试结果的个体差异取决于例如遗传或环境因素，基本上需要更大样本数的进一步研究。(C)2015爱思唯尔有限公司版权所有。
Intranasal oxytocin (OXT) application is emerging as a potential treatment for socio-emotional disorders associated with abnormalities in OXT system (re-) activity. The crucial identification of patients with such abnormalities could be streamlined by the assessment of basal and stimulus-induced OXT concentrations in saliva, using a simple, stress-free sampling procedure (i.e. an OXT challenge test). We therefore established the Regensburg Oxytocin Challenge (ROC) test to further validate salivary OXT concentrations as a practical, reliable and sensitive biomarker.OXT concentrations were quantified by radioimmunoassay in samples collected at home by healthy adult male and female volunteers before and after running ("Run") or sexual self-stimulation ("Sex"). In lactating women, salivary OXT concentrations were quantified before, during and after breastfeeding. Salivary OXT along with salivary cortisol and heart rate were monitored in healthy adult participants undergoing the Trier Social Stress Test (TSST).The home-based "Run" and "Sex" challenges as well as the laboratory-based TSST caused quantifiable, rapid, and consistent increases in salivary OXT (approximately 2.5-fold after 10-15 min), which were similar for men and women. Breastfeeding did not result in measurably increased salivary OXT levels, probably because the short pulses of OXT release characteristic for lactation were missed.Taken together, ROC tests reliably assess the responsiveness of the OXT system (i.e., the increase in salivary OXT concentrations as compared to basal levels) to challenges such as "Run" and "Sex" at home or psychosocial stress (TSST) in the laboratory. Further studies with larger sample numbers are essentially needed in order to reveal individual differences in ROC test outcomes depending on, for example, genetic or environmental factors. (C) 2015 Elsevier Ltd. All rights reserved.