Impact of repetitive transcranial magnetic stimulation on post-stroke dysmnesia and the role of BDNF Val66Met SNP.
Impact of repetitive transcranial magnetic stimulation on post-stroke dysmnesia and the role of BDNF Val66Met SNP.
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DOI：
10.12659/msm.892337
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发表时间：
2015-03-14
期刊：
影响因子：
--
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Lu H;Zhang T;Wen M;Sun L
低频重复经颅磁刺激（rTMS）对记忆障碍的影响以及脑核苷酸神经营养因子（BDNF）Val66Met单核苷酸多态性（SNP）的影响知之甚少。本研究探讨了低频rTMS对脑卒中后记忆障碍的影响以及BDNF Val66Met SNP的影响。40例卒中后记忆障碍患者前瞻性随机分为rTMS组和假手术组。采用限制性片段长度多态性方法检测BDNF Val66Met单核苷酸多态性。在基线和治疗后3天和2个月测量蒙特利尔认知评估（莫卡）、Loewenstein认知评估职业疗法（LOTCA）和Rivermead行为记忆测试（RBMT）评分以及血浆BDNF浓度。rTMS后莫卡、LOTCA和RBMT评分较高。治疗后3d，rTMS组BDNF含量降低，而Sham组BDNF含量升高（P<0.05）。治疗后2个月，rTMS组的RMBT评分高于假手术组，但莫卡和LOTCA评分无差异。低频rTMS可能通过多种途径改善卒中后记忆，这可能涉及多态性和几个神经基因，但不是通过增加BDNF水平。
Little is known about the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on dysmnesia and the impact of brain nucleotide neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphism (SNP). This study investigated the impact of low-frequency rTMS on post-stroke dysmnesia and the impact of BDNF Val66Met SNP. Forty patients with post-stroke dysmnesia were prospectively randomized into the rTMS and sham groups. BDNF Val66Met SNP was determined using restriction fragment length polymorphism. Montreal Cognitive Assessment (MoCA), Loewenstein Occupational Therapy of Cognitive Assessment (LOTCA), and Rivermead Behavior Memory Test (RBMT) scores, as well as plasma BDNF concentrations, were measured at baseline and at 3 days and 2 months post-treatment. MoCA, LOTCA, and RBMT scores were higher after rTMS. Three days after treatment, BDNF decreased in the rTMS group but it increased in the sham group (P<0.05). Two months after treatment, RMBT scores in the rTMS group were higher than in the sham group, but not MoCA and LOTCA scores. Low-frequency rTMS may improve after-stoke memory through various pathways, which may involve polymorphisms and several neural genes, but not through an increase in BDNF levels.