Development of genetic hypotheses in essential hypertension.
Development of genetic hypotheses in essential hypertension.
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原发性高血压遗传假说的发展。
DOI：
10.1007/s100380170063
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Rohrwasser,A
中科院分区：
文献类型：
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作者：
Lalouel,JM;Rohrwasser,A
原发性高血压说明了识别常见疾病的遗传决定因素所提出的艰巨任务。做出最初的遗传推断可能已经足够困难;随后在不同生物整合水平上证明功能意义可能更具挑战性。我们回顾了三个实例，在这些实例中，最初的遗传推断导致了在越来越高的生物组织水平上追求的可检验假设的发展。这些假说包括内收蛋白、G蛋白β3亚基和血管紧张素原假说。
Essential hypertension illustrates the formidable task presented by the identification of genetic determinants of common disease. Making an initial genetic inference may prove difficult enough; the subsequent demonstration of functional significance at various levels of biological integration may be even more challenging. We review three instances in which an initial genetic inference has led to the development of testable hypotheses pursued at increasingly higher levels of biological organization. These include the adducin, the G protein β3 subunit, and the angiotensinogen hypotheses.