Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography
Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography
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DOI：
10.1117/1.jbo.22.6.066010
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发表时间：
2017-06-01
影响因子：
3.5
通讯作者：
Weinreb, Robert N.
中科院分区：
文献类型：
--
作者：
Huang, Alex S.;Belghith, Akram;Weinreb, Robert N.
目的是利用施莱姆管（SC）和一阶收集器通道（CC）的自动检测算法，应用于光谱域光学相干断层扫描（SD-OCT），在活体人眼中建立环向房水流出（ho）的三维（3-D）模型。从一个受试者的前段SD-OCT扫描是在边缘周围获得的。采用贝叶斯脊法对红外共聚焦激光扫描检眼镜图像中SC的位置进行近似，并开发了一种交叉乘法工具，通过模糊隐马尔可夫链方法自动启动SC/ CC检测。SC和初始CC的自动分割由两个掩码分级器手动确定。将分割算法检测到的流出通道重构为AHO的三维表示。总的来说，只有< 1%的图像（5114张b片）是不可分级的。与专家评分者的共识相比，自动分割算法的SC检测率为98.3%，假阳性检测率< 0.1%。CC检出率为84.2%，假阳性检出率为1.4%。ho通路的三维表示显示SC变厚和变薄，有一些清晰的CC根。通过重建，可以实现人眼角度结构的周向（360度）、自动化和经过验证的who检测。(C) 2017年中国光学仪器工程师学会（SPIE）
The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemm's canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. A Bayesian Ridge method was used to approximate the location of the SC on infrared confocal laser scanning ophthalmoscopic images with a cross multiplication tool developed to initiate SC/ CC detection automated through a fuzzy hidden Markov Chain approach. Automatic segmentation of SC and initial CC's was manually confirmed by two masked graders. Outflow pathways detected by the segmentation algorithm were reconstructed into a 3-D representation of AHO. Overall, only < 1% of images (5114 total B-scans) were ungradable. Automatic segmentation algorithm performed well with SC detection 98.3% of the time and < 0.1% false positive detection compared to expert grader consensus. CC was detected 84.2% of the time with 1.4% false positive detection. 3-D representation of AHO pathways demonstrated variably thicker and thinner SC with some clear CC roots. Circumferential (360 deg), automated, and validated AHO detection of angle structures in the living human eye with reconstruction was possible. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).