Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing
Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing
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DOI：
10.1016/s0021-9290(98)00153-5
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发表时间：
1999-03-01
影响因子：
2.4
通讯作者：
Heigele, CA
中科院分区：
文献类型：
--
作者：
Claes, LE;Heigele, CA
本文提出了一种新的定量组织分化理论，它把断裂间隙中局部组织的形成与局部应力应变联系起来。我们的假设提出，应变和静水压力的量沿着现有的钙化表面在骨折骨痂决定骨痂组织的分化。该研究比较了骨痂中的局部应变和应力，如从有限元模型计算的，与从动物骨折模型的组织学结果。该假设预测应变小于约+/- 5%和静水压力小于+/- 0.15 MPa的膜内骨形成。软骨内骨化与大于约-0.15MPa的压缩压力和小于+/-15%的应变相关。所有其他条件似乎导致结缔组织或纤维软骨。这一假说使我们能够更好地理解组织学图像中所见的复杂组织分化和愈合延迟愈合或骨不连的机械条件。(C)1999 Elsevier Science Ltd.保留所有权利。
A new quantitative tissue differentiation theory which relates the local tissue formation in a fracture gap to the local stress and strain is presented. Our hypothesis proposes that the amounts of strain and hydrostatic pressure along existing calcified surfaces in the fracture callus determine the differentiation of the callus tissue. The study compares the local strains and stresses in the callus as calculated from a finite element model with histological findings from an animal fracture model. The hypothesis predicts intramembranous bone formation for strains smaller approximately +/- 5% and hydrostatic pressures smaller than +/- 0.15 MPa. Endochondral ossification is associated with compressive pressures larger than about - 0.15 MPa and strains smaller than +/- 15%. All other conditions seemed to lead to connective tissue or fibrous cartilage. The hypothesis enables a better understanding of the complex tissue differentiation seen in histological images and the mechanical conditions for healing delayed healing or nonunions. (C) 1999 Elsevier Science Ltd. All rights reserved.