Preexisting Neutralizing Antibody Responses Distinguish Clinically Inapparent and Apparent Dengue Virus Infections in a Sri Lankan Pediatric Cohort
Preexisting Neutralizing Antibody Responses Distinguish Clinically Inapparent and Apparent Dengue Virus Infections in a Sri Lankan Pediatric Cohort
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DOI：
10.1093/infdis/jiu481
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发表时间：
2015-02-15
影响因子：
6.4
通讯作者：
de Silva, Aravinda M.
中科院分区：
文献类型：
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作者：
Corbett, Kizzmekia S.;Katzelnick, Leah;de Silva, Aravinda M.
登革病毒（DENV）是感染人类的蚊媒黄病毒。登革病毒感染的临床表现从隐性感染到登革出血热和登革休克综合征不等。我们分析了来自斯里兰卡儿童登革热队列研究的样本，以探讨抗体应答是否区分临床明显感染和临床不明显感染。在暴露于原发性DENV感染的DENV-幼稚个体中，我们观察到隐性感染和显性感染之间获得性抗体的数量或质量没有差异。经历过原发性感染的儿童有广泛的，交叉中和抗体反应，在感染后的12个月内缩小到单一血清型。在经历重复感染的DENV免疫儿童中，我们观察到预先存在的中和抗体与临床结果之间存在很强的相关性。值得注意的是，先前存在单特异性中和抗体反应的儿童比交叉中和反应的儿童更容易出现发热。先前存在的DENV中和抗体与登革热疾病的保护相关。
Dengue viruses (DENVs) are mosquito-borne flaviviruses that infect humans. The clinical presentation of DENV infection ranges from inapparent infection to dengue hemorrhagic fever and dengue shock syndrome. We analyzed samples from a pediatric dengue cohort study in Sri Lanka to explore whether antibody responses differentiated clinically apparent infections from clinically inapparent infections. In DENV-naive individuals exposed to primary DENV infections, we observed no difference in the quantity or quality of acquired antibodies between inapparent and apparent infections. Children who experienced primary infections had broad, serotype-cross-neutralizing antibody responses that narrowed in breadth to a single serotype over a 12-month period after infection. In DENV immune children who were experiencing a repeat infection, we observed a strong association between preexisting neutralizing antibodies and clinical outcome. Notably, children with preexisting monospecific neutralizing antibody responses were more likely to develop fever than children with cross-neutralizing responses. Preexisting DENV neutralizing antibodies are correlated with protection from dengue disease.