Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
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DOI：
10.1126/science.278.5337.477
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发表时间：
1997-10-17
期刊：
影响因子：
56.9
通讯作者：
Greenberg, ME
中科院分区：
文献类型：
--
作者：
Bonni, A;Sun, Y;Greenberg, ME
睫状神经营养因子(CNTF)-白血病抑制因子细胞因子家族的成员调节发育中的哺乳动物中枢神经系统中胶质形成的机制被描述为，CNTF受体的激活促进了大脑皮质前体细胞向星形胶质细胞的分化，并抑制了沿神经元谱系的皮质前体细胞的分化，尽管CNTF刺激了皮质前体细胞中的Janus激酶信号转导和转录激活因子(JAK-STAT)和RAS丝裂原激活的蛋白激酶信号通路，但JAK-STAT信号通路选择性地促进了这些前体沿着胶质谱系的分化。这些发现表明，JAK-STAT信号通路的细胞因子激活可能是哺乳动物发育过程中控制细胞命运的一种机制。
A mechanism by which members of the ciliary neurotrophic factor (CNTF)-leukemia inhibitory factor cytokine family regulate gliogenesis in the developing mammalian central nervous system was characterized, Activation of the CNTF receptor promoted differentiation of cerebral cortical precursor cells into astrocytes and inhibited differentiation of cortical precursors along a neuronal lineage, Although CNTF stimulated both the Janus kinase-signal transducer and activator of transcription (JAK-STAT) and Ras-mitogen-activated protein kinase signaling pathways in cortical precursor cells, the JAK-STAT signaling pathway selectively enhanced differentiation of these precursors along a glial lineage, These findings suggest that cytokine activation of the JAK-STAT signaling pathway may be a mechanism by which cell fate is controlled during mammalian development.