Evidence for a subcortical contribution to intracortical facilitation
Evidence for a subcortical contribution to intracortical facilitation
复制标题
皮质下对皮质内促进的贡献的证据
DOI：
10.1111/ejn.13934
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发表时间：
2018
影响因子：
3.4
通讯作者：
Leukel C
中科院分区：
文献类型：
--
作者：
Wiegel P;Niemann N;Rothwell JC;Leukel C
皮质内易化（ICF）描述了通过在10-15 ms之前给予的前一个阈下脉冲（S1）对经颅磁刺激（TMS）的阈上脉冲（S2）的EMG反应（运动诱发电位）的易化。ICF被广泛认为起源于皮质内机制。在这项研究中，我们使用脊髓H反射来测试皮层下机制是否也有助于促进。对17名健康志愿者的上肢桡侧腕屈肌和16名健康志愿者的下肢比目鱼肌进行了测量。单独给予S2促进H反射。当S1先于S2 10 ms时，易化量增加，与ICF一致。然而，单独给予S1也促进了H反射，表明它引起了下行活动，即使其强度远低于静息运动阈值。在参与者中，单独S1的H反射易化量与S1-S2组合的H反射易化程度成比例。这些结果表明，皮质下机制可以有助于ICF，并可能增加在以前的研究中报告的ICF措施的变异性。
Intracortical facilitation (ICF) describes the facilitation of an EMG response (motor evoked potential) to a suprathreshold pulse (S2) of transcranial magnetic stimulation (TMS) by a preceding subthreshold pulse (S1) given 10–15 ms earlier. ICF is widely assumed to originate from intracortical mechanisms. In this study, we used spinal H‐reflexes to test whether subcortical mechanisms can also contribute to the facilitation. Measurements were performed in the upper limb muscle flexor carpi radialis in 17 healthy volunteers, and in the lower limb muscle soleus in 16 healthy volunteers. S2 given alone facilitated the H‐reflex. When S1 preceded S2 by 10 ms, the amount of facilitation increased, compatible with ICF. However, S1 given alone also facilitated the H‐reflex, suggesting that it had evoked descending activity even though its intensity was well below resting motor threshold. Across participants, the amount of H‐reflex facilitation from S1 alone was proportional to the degree of H‐reflex facilitation with combined S1–S2. These results indicate that subcortical mechanisms can contribute to ICF and potentially add to the variability of the ICF measure reported in previous studies.
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影响因子：
5.5
作者：
COWAN, JMA;DAY, BL;ROTHWELL, JC
通讯作者：
ROTHWELL, JC
影响因子：
1.7
作者：
Burke D
通讯作者：
Burke D
测试齐射激活的突触自生抑制途径对人类 H 反射的抑制
DOI：
10.1113/jphysiol.2002.021683
发表时间：
2002
期刊：
The Journal of Physiology
影响因子：
--
作者：
V. Marchand;G. Nicolas;D. Burke;E. Pierrot‐Deseilligny
通讯作者：
E. Pierrot‐Deseilligny
影响因子：
5.5
作者：
NIELSEN, J;PETERSEN, N;BALLEGAARD, M
通讯作者：
BALLEGAARD, M
影响因子：
5.5
作者：
DAY, BL;DRESSLER, D;THOMPSON, PD
通讯作者：
THOMPSON, PD