Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China
Seroepidemiological evidence of avian H4, H5, and H9 influenza A virus transmission to pigs in southeastern China
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DOI：
10.1016/s0378-1135(02)00105-0
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发表时间：
2002-08-25
影响因子：
3.3
通讯作者：
Kida, H
中科院分区：
文献类型：
--
作者：
Ninomiya, A;Takada, A;Kida, H
对从中国东南部采集的猪血清样品进行了甲型流感病毒抗体检测。由于血凝抑制（HI）试验不能准确检测“禽”流感病毒血凝素（HA）抗体，我们利用中和（NT）试验检测猪血清中禽流感病毒HA亚型特异性抗体。在1977-1982年和1998年采集的血清样品中检测到H1、H3、H4和H5流感病毒的中和抗体，表明在中国的猪中除了猪和人H1和H3病毒之外，还零星地感染了禽H4和H5病毒。另一方面，H9病毒的抗体只在1998年收集的血清中发现，而在1977-1982年收集的血清中没有发现，这与最近在家禽中传播以及随后在1998年从猪和人身上分离出H9 N2病毒有关。目前的结果表明，禽流感病毒已传播到中国东南部的猪群。(C)2002 Elsevier Science B. V.保留所有权利。
Pig serum samples collected in southeastern China were examined for antibodies to influenza A viruses. Since the hemagglutination inhibition (HI) test does not accurately detect antibodies to the hemagglutinins (HAs) of "avian" influenza viruses, we utilized the neutralization (NT) test to detect subtype-specific antibodies to the HA of avian viruses in pig sera. Neutralizing antibodies to H1, H3, H4, and H5 influenza viruses were detected in the serum samples collected in 1977-1982 and 1998, suggesting that pigs in China have been sporadically infected with avian H4 and H5 viruses in addition to swine and human HI and H3 viruses. Antibodies to H9 virus, on the other hand, were found only in the sera collected in 1998, not in those collected in 1977-1982, correlating with the recent spread in poultry and subsequent isolation of H9N2 viruses from pigs and humans in 1998. The present results indicate that avian influenza viruses have been transmitted to pig populations in southeastern China. (C) 2002 Elsevier Science B.V. All rights reserved.