N1-(SUBSTITUTED) PANTOTHENAMIDES, ANTIMETABOLITES OF PANTOTHENIC ACID
N1-(SUBSTITUTED) PANTOTHENAMIDES, ANTIMETABOLITES OF PANTOTHENIC ACID
复制标题
DOI：
10.1016/0003-9861(70)90470-4
复制
发表时间：
1970-01-01
影响因子：
3.9
通讯作者：
SKINNER, CG
中科院分区：
文献类型：
--
作者：
CLIFTON, G;BRYANT, SR;SKINNER, CG
合成了一系列具有一般结构的N1-（取代）泛酸酰胺类似物，并在几种微生物系统中进行了研究。某些衍生物在低至6 μg/ml的浓度下对乳酸菌的生长有抑制作用，在低至0.6 μg/ml的浓度下对大肠杆菌有抑制作用。在阿拉伯乳杆菌和方片球菌中，类似物被泛酸竞争性逆转，抑制指数在30和300之间。抑制生长的类似物在E。大肠杆菌，因为先前潜在的泛酸抗代谢物对该微生物相对无活性。
A series of analogs with the general structureN1-(substituted) pantothenamide has been prepared and studied in several microbiological systems. Certain of these derivatives were inhibitory to growth of lactic acid bacteria at concentrations as low as 6 μg/ml and toEscherichia coliat levels as low as 0.6 μg/ml. InLactobacillus arabinosusandPediococcus cerevisiaethe analogs were competitively reversed by pantothenic acid with inhibition indices between 30 and 300. Inhibition of growth by the analogs inE. coliis of particular interest since previous potential pantothenic acid antimetabolites have been relatively inactive for this microorganism.