Routes to Potentially Safer T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence
Routes to Potentially Safer T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence
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DOI：
10.1021/acsnano.8b03368
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发表时间：
2018-08-01
期刊：
影响因子：
17.1
通讯作者：
Halas, Naomi J.
中科院分区：
文献类型：
--
作者：
Henderson, Luke;Neumann, Oara;Halas, Naomi J.
设计一个紧凑的，近红外等离子体纳米结构与集成的图像增强剂的组合成像和治疗是一个重要的纳米医学挑战。最近，我们发现Au@SiO2@Au nanomatryoshkas（NM）是一种非常有前途的纳米结构，用于托管T-1 MRI或荧光造影剂，具有紧凑的几何结构中的光热治疗反应3。在这里，我们表明，近红外共振NM可以提供同时的对比度增强T-1磁共振成像（MRI）和荧光光学成像（FOI）通过封装两种类型的造影剂之间的内部二氧化硅层的Au的核心和外壳。我们还表明，这种T-1增强方法对Fe（III）更有效，与Gd（III）相比，Fe（III）是一种潜在的更安全的造影剂。发现Fe-NM基造影剂的弛豫率比广泛使用的钆螯合物Gd（III）DOTA的弛豫率大2倍，提供了一种实际的替代方案，可以完全消除Gd（III）患者暴露。这种双模态纳米结构不仅可以实现MRI的组织可视化，还可以实现基于荧光的纳米颗粒跟踪，用于量化体内纳米颗粒分布，以及近红外光热治疗反应。
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently, we showed that Au@SiO2@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T-1 MRI or fluorescent contrast agents with a photothermal therapeutic response 3 in a compact geometry. Here, we show that a near-infrared resonant NM can provide simultaneous contrast enhancement for both T-1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell. We also show that this method of T-1 enhancement is even more effective for Fe(III), a potentially safer contrast agent compared to Gd(III). Fe-NM-based contrast agents are found to have relaxivities 2x greater than those found in the widely used gadolinium chelate, Gd(III) DOTA, providing a practical alternative that would eliminate Gd(III) patient exposure entirely. This dual-modality nanostructure can enable not only tissue visualization with MRI but also fluorescence-based nanoparticle tracking for quantifying nanoparticle distributions in vivo, in addition to a near-infrared photothermal therapeutic response.