High concentrations of 17beta -estradiol attenuate the exercise pressor reflex in male cats.
High concentrations of 17beta -estradiol attenuate the exercise pressor reflex in male cats.
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高浓度的 17β-雌二醇会减弱雄性猫的运动升压反射。
DOI：
10.1152/japplphysiol.00825.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kaufman,MarcP
中科院分区：
文献类型：
--
作者：
Schmitt,PetraM;Kaufman,MarcP
Previously, intravenous injection of 17β-estradiol in decerebrate male cats was found to attenuate central command but not the exercise pressor reflex. This latter finding was surprising because the dorsal horn, the spinal site receiving synaptic input from thin-fiber muscle afferents, is known to contain estrogen receptors. We were prompted, therefore, to reexamine this issue. Instead of injecting 17β-estradiol intravenously, we applied it topically to the L7and S1spinal cord of male decerebrate cats. We found that topical application (150–200 μl) of 17β-estradiol in concentrations of 0.01, 0.1, and 1 μg/ml had no effect on the exercise pressor reflex, whereas a concentration of 10 μg/ml attenuated the reflex. We conclude that, in male cats, estrogen can only attenuate the exercise pressor reflex in concentrations that exceed the physiological level.
