Quantification of bone marrow fat content using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): reproducibility, site variation and correlation with age and menopause
Quantification of bone marrow fat content using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): reproducibility, site variation and correlation with age and menopause
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DOI：
10.1259/bjr.20150538
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发表时间：
2016-01-01
影响因子：
2.6
通讯作者：
Korogi, Yukunori
中科院分区：
文献类型：
--
作者：
Aoki, Takatoshi;Yamaguchi, Shinpei;Korogi, Yukunori
目的：探讨基于多回声梯度回波序列[具有不对称回声的水脂迭代分解和最小二乘估计定量序列(Idea-IQ)]定量水脂肪分离法测定骨髓脂肪分数的重复性；评价不同部位骨脂分数的变化；探讨其与年龄和绝经的关系。方法：31例连续接受盆腔不对称水脂迭代分解的女性患者，在3-T磁共振成像上进行最小二乘估计。用Idea-IQ对四个骨部位的FF值进行定量分析。每个部位的变异系数(CV)重复评估10次，以评估其重复性。结果：骨髓FF定量的变异系数在0.69%~1.70%之间。在腰椎体、髂骨和股骨粗隆间区域，FF与年龄之间存在显著的统计学相关性(p<；0.001)。这些部位绝经后女性的平均FF值显著高于绝经前女性(P<；0.05)。结论：在活体条件下，理想智商可以提供可靠的骨髓脂肪定量。知识进展：理想智商在短时间内操作简单，可能在临床上提供骨质量的信息。
Objective: To determine the reproducibility of the quantitative chemical shift-based water-fat separation method with a multiecho gradient echo sequence [iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ)] for assessing bone marrow fat fraction (FF); to evaluate variation of FF at different bone sites; and to investigate its association with age and menopause.Methods: 31 consecutive females who underwent pelvic iterative decomposition of water and fat with echo asymmetry and least-squares estimation at 3-T MRI were included in this study. Quantitative FF using IDEAL-IQ of four bone sites were analyzed. The coefficients of variance (CV) on each site were evaluated repeatedly 10 times to assess the reproducibility. Correlations between FF and agewere evaluated on each site, and the FFs between pre- and post-menopausal groups were compared.Results: The CV in the quantification of marrow FF ranged from 0.69% to 1.70%. A statistically significant correlation was established between the FF and the age in lumbar vertebral body, ilium and intertrochanteric region of the femur (p < 0.001). The average FF of postmenopausal females was significantly higher than that of pre-menopausal females in these sites (p < 0.05). In the greater trochanter of the femur, there was no significant correlation between FF and age.Conclusion: In vivo IDEAL-IQ would provide reliable quantification of bone marrow fat.Advances in knowledge: IDEAL-IQ is simple to perform in a short time and may be practical for providing information on bone quality in clinical settings.