T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis.
T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis.
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DOI：
10.1128/mbio.02087-17
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发表时间：
2017-12-12
期刊：
影响因子：
6.4
通讯作者：
Robinson RT
中科院分区：
文献类型：
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作者：
Robinson RT
粒细胞-巨噬细胞集落刺激因子（GM-CSF）虽然与骨髓生成有关，但越来越多地被认为对结核病（TB）耐药具有重要意义。GM-CSF在结核分枝杆菌感染后由非造血和造血谱系表达，并且在实验模型中是限制结核分枝杆菌生长所必需的。直到Rothchild等人最近的研究（mBio 8：e01514-17，2017，https：//doi.org/10.1128/mBio.01514-17），还不知道产生GM-CSF的T细胞是否有助于结核病耐药性。Rothchild等人鉴定了在实验性TB期间哪些常规和非常规T细胞亚群产生GM-CSF，使用多种方法建立了它们的保护性质，并为它们限制结核分枝杆菌生长的能力提供了机制基础。这篇评论讨论了这些发现对基础和应用结核病研究的意义。当转化为人类疾病时，这些发现表明疫苗介导的产生GM-CSF的T细胞的扩增可能是有效的预防或治疗TB策略。
Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy.