New members of the platelet-derived growth factor family of mitogens
New members of the platelet-derived growth factor family of mitogens
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DOI：
10.1006/abbi.2001.2707
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发表时间：
2002-02-15
影响因子：
3.9
通讯作者：
Östman, A
中科院分区：
文献类型：
--
作者：
Heldin, CH;Eriksson, U;Östman, A
血小板衍生生长因子（PDGF）2是一个二硫键二聚体亚型家族，主要作用于结缔组织细胞（25）。PDGF同种型最初从血小板中分离，但随后发现由许多不同的细胞类型产生。由于其对结缔组织细胞的生长和趋化性的有效刺激，PDGF促进软组织损伤的愈合。此外，PDGF在胚胎发育过程中具有重要作用，特别是在肾脏、血管和各种结缔组织隔室的形成中。然而，PDGF的过度活性与不同类型的疾病有关，包括动脉粥样硬化、纤维化疾病和恶性肿瘤。事实上，转化癌基因sis编码PDGF样生长因子，其通过自分泌机制转化细胞。传统上，PDGF同种型由A-和B-多肽链的同源和异源二聚体组成。有趣的是，最近发现了血小板衍生生长因子家族的两个新成员，即血小板衍生生长因子-C（40）和血小板衍生生长因子-D（3，36）。本综述将总结不同的PDGF亚型的结构和功能特性。
Platelet-derived growth factor (PDGF) 2 is a family of disulfide-bonded dimeric isoforms, which act mainly on connective tissue cells (25). PDGF isoforms were originally isolated from platelets, but have subsequently been found to be produced by many different cell types. Due to its potent stimulation of growth and chemotaxis of connective tissue cells, PDGF promotes healing of injuries of soft tissue. In addition, PDGF has important roles during the embryonal development, particularly in the formation of the kidney, blood vessels, and various connective tissue compartments. However, overactivity of PDGF has been linked to different types of disorders, including atherosclerosis, fibrotic diseases, and malignancies. In fact, the transforming oncogene sis encodes a PDGF-like growth factor which transforms cells by an autocrine mechanism. Traditionally, the PDGF isoforms consisted of homoand heterodimers of A-and B-polypeptide chains. Interestingly, two novel members of the PDGF family were recently identified, ie, PDGF-C (40) and PDGF-D (3, 36). The present review will summarize the structural and functional properties of the different PDGF isoforms.