Movement Directionality in Collective Migration of Germ Layer Progenitors
Movement Directionality in Collective Migration of Germ Layer Progenitors
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DOI：
10.1016/j.cub.2009.11.036
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发表时间：
2010-01-26
期刊：
影响因子：
9.2
通讯作者：
Heisenberg, Carl-Philipp
中科院分区：
文献类型：
--
作者：
Arboleda-Estudillo, Yohanna;Krieg, Michael;Heisenberg, Carl-Philipp
集体细胞迁移，通过细胞-细胞粘附连接的多个细胞的同时运动，在发育、组织修复和肿瘤转移中普遍存在[1，2]。有人假设，集体迁移过程中细胞运动的方向性是一种集体属性[3，4]。在这里，我们确定如何运动方向性建立在集体中内胚层迁移在斑马鱼原肠胚。通过干扰集体迁移的两个关键特征，（1）具有相邻细胞和（2）粘附于它们，我们表明单个中内胚层细胞在作为单个细胞移动时能够正常定向迁移，但在作为群体的一部分移动时需要细胞-细胞粘附以参与协调和定向迁移。我们的结论是，运动方向性是不是一个从头的中内胚层细胞的集体财产，而是一个属性的单个中内胚层细胞，需要在集体迁移过程中的细胞-细胞粘附。
Collective cell migration, the simultaneous movement of multiple cells that are connected by cell-cell adhesion, is ubiquitous in development, tissue repair, and tumor metastasis [1, 2]. It has been hypothesized that the directionality of cell movement during collective migration emerges as a collective property [3, 4]. Here we determine how movement directionality is established in collective mesendoderm migration during zebrafish gastrulation. By interfering with two key features of collective migration, (1) having neighboring cells and (2) adhering to them, we show that individual mesendoderm cells are capable of normal directed migration when moving as single cells but require cell-cell adhesion to participate in coordinated and directed migration when moving as part of a group. We conclude that movement directionality is not a de novo collective property of mesendoderm cells but rather a property of single mesendoderm cells that requires cell-cell adhesion during collective migration.