Myasthenic syndrome associated with antibiotics.
Myasthenic syndrome associated with antibiotics.
复制标题
与抗生素相关的肌无力综合征。
DOI：
10.1001/archneur.1968.00470340088008
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
J. O'Rourke
中科院分区：
文献类型：
--
作者：
M. Mcquillen;H. A. Cantor;J. O'Rourke
抗生素通过干扰神经肌肉传递而产生虚弱。1941年，在实验动物中首次观察到呼吸暂停，并使用了第一种临床应用的抗生素--短杆菌素。1 1956年，在腹腔内感染硫酸新霉素后，报告了第一例人类长时间呼吸暂停。[2]自1956年以来，一种以呼吸无力、弛缓性麻痹、瞳孔和视力变化为特征的综合征被认为与多种抗生素有关。3-50根据定义，这种“肌无力综合征”发生在没有重症肌无力的患者中，尽管一些肌无力患者在给予某些抗生素后变得更弱。[51]最近对抗生素毒性的综述并没有强调这种综合征[52-54]仅在4名患者中提到了肌电图（EMG）研究。1例神经肌肉传递和神经传导速度正常。[49]在另一组中出现了“currarelike”30或非去极化34，50效应。在一个病人50的阻滞没有改变依酚氯铵。深刻
ANTIBIOTICS produce weakness by interfering with neuromuscular transmission. Apnea in experimental animals was observed first in 1941 with tyrothricin, the first antibiotic tested for clinical application. 1 In 1956, the first case of prolonged apnea in man was reported after intraperitoneally infected neomycin sulfate. 2 Since 1956, a syndrome characterized by respiratory weakness, flaccid paralysis, and pupillary and visual changes has been recognized in association with a number of antibiotics. 3-50 As defined, this "myasthenic syndrome" occurs in patients who do not have myasthenia gravis, although some myasthenics become weaker when given certain antibiotics. 51 Recent reviews of antibiotic toxicity do not emphasize this syndrome 52-54 Electromyographic (EMG) studies were mentioned in only four patients. In one, neuromuscular transmission and nerve conduction velocities were normal. 49 A "currarelike" 30 or nondepolarizing 34,50 effect occurred in the others. In one patient 50 the block was not altered by edrophonium chloride. Profound