Cardiovascular effects of an L/N-type Ca2+ channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs.
Cardiovascular effects of an L/N-type Ca2+ channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs.
复制标题
L/N 型 Ca2 通道阻滞剂西尼地平对慢性房室传导阻滞犬的心血管作用进行了评估。
DOI：
10.1254/jphs.scj04007x
复制
发表时间：
2004
影响因子：
3.5
通讯作者：
K. Hashimoto
中科院分区：
文献类型：
--
作者：
A. Takahara;A. Sugiyama;Y. Satoh;Yuji Nakamura;K. Hashimoto
本文观察了L/N型钙通道双重阻滞剂西尼地平对慢性房室传导阻滞犬的心血管作用。用药前对照犬全身血压和血浆儿茶酚胺水平显著升高。西尼地平降压剂量(1微克/公斤和3微克/公斤，静脉注射)显著降低总外周血管阻力、平均血压、心房率，增加心输出量。这些结果表明，西尼地平不仅能降低血压，而且在体内高血压状态下，随着肾上腺素能张力的增加，窦房结的自律性也降低。
Cardiovascular effects of cilnidipine, a dual L/N-type Ca2+ channel blocker, were evaluated in the chronic atrioventricular block dogs, of which systemic blood pressure and plasma catecholamine levels significantly increased in the pre-drug control. Administration of antihypertensive doses of cilnidipine (1 and 3 microg/kg, i.v.) significantly decreased the total peripheral vascular resistance, mean blood pressure, and atrial rate and increased the cardiac output. These results suggest that cilnidipine not only decreases the blood pressure, but also decreases the sinus automaticity in the in vivo hypertensive condition with increased adrenergic tones.