CREB, cellular excitability, and cognition: Implications for aging.
CREB, cellular excitability, and cognition: Implications for aging.
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Creb，细胞兴奋性和认知：对衰老的影响。
DOI：
10.1016/j.bbr.2016.07.042
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发表时间：
2017-03-30
影响因子：
2.7
通讯作者：
Disterhoft JF
中科院分区：
文献类型：
--
作者：
Yu XW;Oh MM;Disterhoft JF
随着年龄的增长，人类和实验动物表现出认知缺陷。然而，目前还没有有效的治疗方法来治疗这些缺陷，因为人们对其潜在的机制知之甚少。使用药理学化合物的研究发现认知表现与海马神经元CA1的内在细胞兴奋性之间存在联系。因此，确定可能影响认知和神经元兴奋性的分子调节因子是非常有趣的，这些调节因子可能随着年龄的增长而改变。一个可能的调节因子是转录因子cAMP反应元件结合蛋白（CREB）。在年轻的成年动物中，操纵CREB活动导致行为任务的认知表现和神经元兴奋性的调节。虽然证据很少，但研究也指出CREB信号随着年龄的增长而出现功能障碍。我们建议CREB可能是治疗与年龄相关的认知缺陷的可行治疗靶点，以及潜在的实验来验证这一假设。
Humans and laboratory animals display cognitive deficits as they age. However, there are currently no effective therapies available to treat these deficits, as the underlying mechanisms are poorly understood. Studies using pharmacological compounds have found a link between cognitive performance and the intrinsic cellular excitability of CA1 hippocampal neurons. Therefore, it is of great interest to identify molecular regulators that may be influencing both cognition and neuronal excitability, which could be changed with age. One possible regulator is the transcription factor cAMP response element binding-protein (CREB). In young adult animals, manipulation of CREB activity has resulted in modulation of both cognitive performance on behavioral tasks, and neuronal excitability. While evidence is sparse, studies also point to a dysfunction in CREB signaling with aging. We propose that CREB may be a viable therapeutic target for the treatment of age-related cognitive deficits, along with potential experiments to test this hypothesis.