Rapid Development of Targeting circRNAs in Cardiovascular Diseases.
Rapid Development of Targeting circRNAs in Cardiovascular Diseases.
复制标题
心血管疾病中靶向 circRNA 的快速发展。
DOI：
10.1016/j.omtn.2020.06.022
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yang Burton B
中科院分区：
文献类型：
--
作者：
Zhang Chao;Huo Si Tong;Wu Zhiyong;Chen Lina;Wen Chang;Chen Honghao;Du William W;Wu Nan;Guan Daogang;Lian Sen;Yang Burton B
环状RNA(CircRNAs)是共价连接的环状单链RNA。CircRNAs在组织中含量丰富，具有发育阶段特异性表达，参与多种生理和病理过程。在本文中，我们讨论了CircRNAs作为心血管疾病的生物标志物和治疗靶点的发展，重点介绍了突出机遇和挑战的外体CircRNAs的最新发现和应用。一些研究已经确定了一系列在心血管疾病中差异表达的CircRNA，而另一些研究则进一步操纵了特定的CircRNA表达，并显示出改善的致病状态，如缺血性损伤、肥大和心肌纤维化。CircRNAs的研究和应用正在迅速发展。我们希望在不久的将来看到CircRNAs作为疾病治疗的生物标记物和靶点的临床使用。
Circular RNAs (circRNAs) are circularized, single-stranded RNAs that are covalently linked. With their abundance in tissues and developmental stage-specific expression, circRNAs participate in a variety of physiological and pathological processes. In this review, we discuss the development of circRNAs used as biomarkers and therapeutic targets for cardiovascular diseases (CVDs), focusing on recent discoveries and applications of exosomal circRNAs that highlight opportunities and challenges. Some studies have identified a spectrum of circRNAs that are differentially expressed in CVDs, while other studies further manipulated specific circRNA expression and showed an ameliorated pathogenic state such as ischemic injury, hypertrophy, and cardiac fibrosis. Studies and applications of circRNAs are being rapidly developed. We expect to see clinical use of circRNAs as biomarkers and targets for disease treatment in the near future.