Mutation of a single lytic transglycosylase causes aberrant septation and inhibits cell separation of Neisseria gonorrhoeae
Mutation of a single lytic transglycosylase causes aberrant septation and inhibits cell separation of Neisseria gonorrhoeae
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DOI：
10.1128/jb.186.22.7811-7814.2004
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发表时间：
2004-11-01
影响因子：
3.2
通讯作者：
Dillard, JP
中科院分区：
文献类型：
--
作者：
Cloud, KA;Dillard, JP
裂解性肽聚糖转糖基酶的功能知之甚少。大肠杆菌的单一裂解转糖基酶突变体没有生长表型。相比之下，淋球菌ltgC的突变抑制细胞分离而不影响肽聚糖单体的产生。因此，LtgC在淋球菌细胞分裂中具有专用功能。
The function of lytic peptidoglycan transglycosylases is poorly understood. Single lytic transglycosylase mutants of Escherichia coli have no growth phenotype. By contrast, mutation of Neisseria gonorrhoeae ltgC inhibited cell separation without affecting peptidoglycan monomer production. Thus, LtgC has a dedicated function in gonococcal cell division.