Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation
Cerebral blood flow is not affected during perfluorocarbon dosing with volume-controlled ventilation
复制标题
DOI：
10.1111/jpc.12297
复制
发表时间：
2013-12-01
影响因子：
1.7
通讯作者：
Colditz, Paul B.
中科院分区：
文献类型：
--
作者：
Davies, Mark W.;Dunster, Kimble R.;Colditz, Paul B.
目的全氟碳化合物给药增加脑血流量。这可以通过调节压力控制通气来防止二氧化碳的上升来缓解。容量控制通气应防止动脉二氧化碳和脑血流量增加。本研究旨在确定在使用容量控制通气时，在给予10 mL/kg的全氟化碳期间是否增加脑血流量。MethodsTwo New Zealand白色兔，用容量控制通气，各自被分配到六个给药事件，其中每个给药事件被随机分配到两个给药策略之一：对照组-给予假剂量的空气（10 mL/kg）超过20 min;部分液体通气组：FC-77 10 mL/kg，20 min内缓慢给药。在每次给药事件开始前1分钟和开始后30分钟记录数据。没有调整通气（除吸入氧气的分数），允许在每个剂量events.ResultsThere没有显着的变化，随着时间的推移，颈动脉血流量组间无差异（P = 0.48，在剂量结束）。两组的皮质脑血流量均轻微增加;组间无统计学显著差异（结束剂量时P = 0.56，最大差异时P = 0.49）。组间无差异的变异性颈动脉血流量或皮质脑血流量。ConclusionsCerebral blood flow was not significantly increased during administration of a dose of 10 mL/kg of perfluorocarbon during beginning of partial liquid ventilation when using volume-controlled ventilation.
AimsPerfluorocarbon administration increases cerebral blood flow. This can be mitigated by preventing a rise in carbon dioxide by adjusting pressure-controlled ventilation. Volume-controlled ventilation should prevent increases in arterial carbon dioxide and cerebral blood flow. This study aims to determine if cerebral blood flow is increased during administration of 10mL/kg of perfluorocarbon while using volume-controlled ventilation.MethodsTwo New Zealand white rabbits, ventilated with volume-control, were each allocated to six dosing events where each dosing event was randomly allocated to one of two dosing strategies: a control group - given a sham dose of air (10mL/kg) over 20min; or a partial liquid ventilation group - given 10mL/kg FC-77 slowly over 20min. Data were recorded for 1min before and 30min after the start of each dosing event. No adjustment of ventilation (except fraction of inspired oxygen) was allowed during each dosing event.ResultsThere were no significant changes over time and no differences between groups for carotid blood flow (P = 0.48 at the end of the dose). There were slight increases in cortical cerebral blood flow in both groups; there was no statistically significant difference between groups (P = 0.56 at end dose and P = 0.49 at time of maximum difference). There was no difference between groups for the variability in carotid blood flow or cortical cerebral blood flow.ConclusionsCerebral blood flow was not significantly increased during administration of a dose of 10mL/kg of perfluorocarbon during commencement of partial liquid ventilation when using volume-controlled ventilation.