MR-guided stereotactic laser ablation of epileptogenic foci in children
MR-guided stereotactic laser ablation of epileptogenic foci in children
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DOI：
10.1016/j.yebeh.2012.04.135
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发表时间：
2012-08-01
影响因子：
2.6
通讯作者：
Wilfong, Angus A.
中科院分区：
文献类型：
--
作者：
Curry, Daniel J.;Gowda, Ashok;Wilfong, Angus A.
目的：约30%的癫痫患者药物治疗无效。MR引导激光间质热疗（MRgLITT）允许对消融过程进行实时热监测，并对激光能量输送进行反馈控制。我们报告的微创手术技术MRgLITT和短期随访结果，从第一个五个儿科病例中，该系统被用来消融局灶性epileptic lesions.Methods：我们研究了患者的大脑MRI，定位癫痫发作与video-EEG和使用Visualase热治疗25系统激光消融他们的癫痫灶。结果：所有5例患者均无癫痫发作，2-13个月随访无并发症。结论：MR引导下的激光间质热疗具有显着的潜力，是一种微创替代更传统的技术手术治疗难治性癫痫儿童。(C)2012 Elsevier Inc. All rights reserved.
Objective: For about 30% of epilepsy patients, pharmaceutical therapy fails to control their seizures. MR-guided laser interstitial thermal therapy (MRgLITT) allows for real-time thermal monitoring of the ablation process and feedback control over the laser energy delivery. We report on minimally invasive surgical techniques of MRgLITT and short-term follow-up results from the first five pediatric cases in which this system was used to ablate focal epileptic lesions.Methods: We studied the patients with MRI of the brain, localized the seizure with video-EEG and used the Visualase Thermal Therapy 25 System for laser ablation of their seizure foci.Results: All 5 patients are seizure free and there were no complications as of 2-13-month follow-up.Conclusion: MR-guided laser interstitial thermal therapy has a significant potential to be a minimally invasive alternative to more conventional techniques to surgically treat medically refractory epilepsy in children. (C) 2012 Elsevier Inc. All rights reserved.