All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank.
All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank.
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DOI：
10.1111/acer.14968
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发表时间：
2022-12
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影响因子：
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大量饮酒与死亡率增加有关。我们的目的是确定影响饮酒过量者死亡率的因素。我们从英国生物银行获得了2006-2010年基线评估时约50万名40-70岁参与者的信息。在生存分析中使用了5136名男性（占男性参与者的2.20%）和1504名女性（占0.60%）的习惯性酒精摄入量、生活方式和生理数据、实验室检查结果以及医院诊断和死亡证明数据（截至2020年6月），这些人分别报告摄入≥80或≥50 g/天。与所有其他参与者相比，这些过度饮酒者的死亡风险比为2.02（95% CI 1.89-2.17），所有原因为1.89（1.69-2.12），任何癌症为1.87（1.61-2.17），任何肝脏疾病为9.40（7.00-12.64）。肝病诊断或肝功能检查异常不仅可以预测肝病导致的死亡，还可以预测癌症或循环系统疾病导致的死亡。过量饮酒者的死亡率也与定量饮酒、诊断的酒精依赖、有害使用或戒断综合征以及评估时的当前吸烟有关。慢性过量饮酒的人平均生存率降低，但其死亡率有很大差异，肝脏异常和酒精依赖或其他酒精使用障碍与预后不良相关。临床上，具有这些危险因素和高酒精摄入的患者应考虑早期或强化管理。研究可以有效地集中在诱发依赖或肝脏异常的因素上。高酒精摄入会增加死亡率，但对影响高危饮酒者死亡率的风险因素知之甚少。我们评估了6640名UKB参与者，他们报告每天饮酒量> 80 g/50 g（男性/女性）。酒精使用障碍、肝病诊断、肝功能检查和红细胞形态异常预测总体死亡风险较高，以及肝病、癌症或心血管疾病。与所有其他参与者相比，所有原因，癌症，循环系统疾病的死亡率风险比约为2倍，任何肝脏疾病的死亡率风险比>9倍。
High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts of alcohol. We obtained information from the UK Biobank on approximately 500,000 participants aged 40–70 years at baseline assessment in 2006–2010. Habitual alcohol intake, lifestyle and physiological data, laboratory test results, and hospital diagnoses and death certificate data (to June 2020) for 5136 men (2.20% of male participants) and 1504 women (0.60%) who reported consuming ≥80 or ≥50 g/day, respectively, were used in survival analysis. Mortality hazard ratios for these excessive drinkers, compared to all other participants, were 2.02 (95% CI 1.89–2.17) for all causes, 1.89 (1.69–2.12) for any cancer, 1.87 (1.61–2.17) for any circulatory disease, and 9.40 (7.00–12.64) for any liver disease. Liver disease diagnosis or abnormal liver function tests predicted not only deaths attributed to liver disease but also those from cancers or circulatory diseases. Mortality among excessive drinkers was also associated with quantitative alcohol intake; diagnosed alcohol dependence, harmful use, or withdrawal syndrome; and current smoking at assessment. People with chronic excessive alcohol intake experience decreased average survival, but there is substantial variation in their mortality, with liver abnormality and alcohol dependence or other alcohol use disorders associated with a worse prognosis. Clinically, patients with these risk factors and high alcohol intake should be considered for early or intensive management. Research can usefully focus on the factors predisposing to dependence or liver abnormality. High alcohol intake increases mortality but little is known about risk factors which affect mortality in high‐risk drinkers. We assessed 6640 UKB participants reporting >80g/50g (men/women) alcohol per day. Alcohol use disorders, diagnosis of liver disease, abnormal liver function tests and erythrocyte morphology predicted higher risk of death overall, and from liver disease, cancers or cardiovascular diseases. Mortality Hazard Ratios, compared to all other participants, were ~2‐fold for all causes, cancers, circulatory diseases, and >9‐fold for any liver disease.
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影响因子：
17.7
作者：
Mallard, Travis T.;Savage, Jeanne E.;Johnson, Emma C.;Huang, Yuye;Edwards, Alexis C.;Hottenga, Jouke J.;Grotzinger, Andrew D.;Gustavson, Daniel E.;Jennings, Mariela, V;Anokhin, Andrey;Dick, Danielle M.;Edenberg, Howard J.;Kramer, John R.;Lai, Dongbing;Meyers, Jacquelyn L.;Pandey, Ashwini K.;Harden, Kathryn Paige;Nivard, Michel G.;de Geus, Eco J. C.;Boomsma, Dorret, I;Agrawal, Arpana;Davis, Lea K.;Clarke, Toni-Kim;Palmer, Abraham A.;Sanchez-Roige, Sandra
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