Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses
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DOI：
10.1016/j.vaccine.2008.05.011
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发表时间：
2008-07-04
期刊：
影响因子：
5.5
通讯作者：
Le Souef, Peter N.
中科院分区：
文献类型：
--
作者：
Baynam, Gareth;Zhang, Guicheng;Le Souef, Peter N.
细胞因子基因的多态会影响疫苗的反应，许多表型都有性别特异性的影响。因此，这项研究调查了细胞因子基因多态性对疫苗应答的性别特异性影响。在263名有父母特应性病史的2岁儿童中，携带IL-4 C-589T和IL-4Rα150V与特应性相关的男孩相比，白喉类毒素(Diphtox)和破伤风类毒素(TetTox)应答增加(IL-4C-589T：DipTox p=0.01，TetTox p=0.04；IL-4Rα150V：DipTox p=0.04，TetTox p=0.08)。相反，与其他等位基因相比，携带IL-10-592C等位基因的女孩对DiphTox(p=0.03)和TetTox(p=0.02)的反应水平较低。此外，114C-589T(p=0.01)和IL-4Rα150V(p=0.04)基因多态性也存在交互作用。总而言之，这些发现支持了主要遗传和修饰因素对疫苗应答的相互作用，以及特应性遗传学对这些应答的重要性。(C)2008爱思唯尔有限公司。保留所有权利。
Cytokine gene polymorphisms affect vaccine responses and gender-specific effects are known for many phenotypes. Therefore, this study investigated gender-specific effects of cytokine gene polymorphisms on vaccine responses. In 263 2-year-old subjects selected for parental history of atopy, boys with IL-4 C-589T and IL-4R alpha 150V genotypes associated with atopy had increased Diptheria Toxoid (DiphTox) and Tetanus Toxoid (TetTox) responses compared with the remaining alleles (IL-4 C-589T: DipTox p = 0.01, TetTox p = 0.04; lL-4R alpha.150V: DipTox p = 0.04, TetTox p = 0.08). Contrastingly, girls with IL-10-592C genotypes associated with atopy had lower levels of DiphTox (p = 0.03) and TetTox (p = 0.02) responses compared with the remaining allele. Additionally, interaction effects were found for 114 C-589T (p = 0.01) and IL-4R alpha 150V (p = 0.04) polymorphisms. In conclusion, these findings support the interaction of primary genetic and modifying factors on vaccine responses and the importance of atopic genetics to these responses. (C) 2008 Elsevier Ltd. All rights reserved.