Buprenorphine in the United States: Motives for abuse, misuse, and diversion
Buprenorphine in the United States: Motives for abuse, misuse, and diversion
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DOI：
10.1016/j.jsat.2019.07.005
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发表时间：
2019-09-01
影响因子：
3.9
通讯作者：
Dunn, Kelly E.
中科院分区：
文献类型：
--
作者：
Chilcoat, Howard D.;Amick, Halle R.;Dunn, Kelly E.
阿片类药物使用障碍（OUD）及其后果是一个重大的公共卫生问题。部分激动剂丁丙诺啡是一种安全有效的治疗OUD的药物，但丁丙诺啡的滥用、误用和转移引起了人们的担忧。该叙述性审查审查了美国非法丁丙诺啡使用的比率和动机。纳入的17项研究的结果表明，大多数使用非法丁丙诺啡的研究参与者是出于与滥用有关的原因（管理阿片类药物戒断症状或实现或维持对其他阿片类药物的戒断）。较小比例的研究应答者报告使用丁丙诺啡的原因与滥用有关（获得高）。对丁丙诺啡的需求与获得适当治疗之间似乎存在差距。减少与政策有关的障碍和治疗界采用适当的丁丙诺啡使用是继续努力减少与OUD相关的负担的关键工具。
Opioid use disorder (OUD) and its consequences are a major public health concern. The partial agonist buprenorphine is a safe and effective treatment for OUD, but concerns about abuse, misuse, and diversion of buprenorphine have been raised. This narrative review examined the rates and motives for use of illicit buprenorphine in the United States. Findings from the 17 included studies suggest the majority of study participants using illicit buprenorphine do so for reasons related to misuse (to manage opioid withdrawal symptoms or achieve or maintain abstinence from other opioids). A smaller percentage of study respondents reported using buprenorphine for reasons related to abuse (to get high). There appears to be a gap between need for buprenorphine and access to adequate treatment. Attenuation of policy-related barriers and adoption of appropriate buprenorphine use by the treatment community are critical tools in the continued effort to reduce the burdens associated with OUD.