Neuropsychological correlates of apathy and depression in patients with dementia
Neuropsychological correlates of apathy and depression in patients with dementia
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DOI：
10.1212/wnl.52.7.1403
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发表时间：
1999-04-22
期刊：
影响因子：
9.9
通讯作者：
Starkstein, SE
中科院分区：
文献类型：
--
作者：
Kuzis, G;Sabe, L;Starkstein, SE
目的：探讨AD患者情感淡漠与抑郁及特异性认知功能障碍的关系。背景：冷漠和抑郁是AD患者常见的行为障碍。然而，这些疾病的神经心理学相关性很少被检查。研究方法：对72例伴冷漠和抑郁的AD患者、29例仅伴冷漠的AD患者、31例仅伴抑郁的AD患者和52例既无冷漠也无抑郁的AD患者（对照组）进行神经心理学和精神病学综合评估。结果如下：与无情感淡漠的患者相比，情感淡漠的患者在言语记忆、命名、定势转换和言语流畅性测试中的得分显著降低。在抽象思维测试中，与冷漠相比，抑郁和冷漠的关联产生了更严重的缺陷。最后，与AD对照组相比，没有冷漠的抑郁症与更严重的认知障碍无关。结论：冷漠，而不是抑郁，与更严重的额叶相关的认知缺陷的AD。
Objective: To investigate the association between apathy and depression, and specific cognitive deficits in AD. Background: Apathy and depression are frequent behavioral disorders in patients with AD. However, the neuropsychological correlates of these disorders have rarely been examined. Methods: A comprehensive neuropsychological and psychiatric evaluation was carried out in 72 patients with AD with apathy and depression, 29 patients with AD with apathy only, 31 patients with AD with depression only, and 52 patients with AD with neither apathy nor depression (control group). Results: Patients with apathy had significantly lower scores on tests of verbal memory, naming, set shifting, and verbal fluency compared with patients without apathy. The association of depression and apathy produced significantly more severe deficits compared with apathy only on a test of abstract thinking. Finally, depression in the absence of apathy was not associated with more severe cognitive impairments compared with the AD control group. Conclusions: Apathy, but not depression, is associated with significantly more severe frontal lobe related cognitive deficits in AD.